TRIM家族蛋白在病毒感染中作用的研究进展

Role of TRIM family proteins in viral infection

摘要:

三基序蛋白家族(tripartite motif, TRIM)是参与不同细胞功能的一大类具有E3泛素连接酶活性的蛋白质，在宿主抗病毒免疫应答中发挥着重要的作用。TRIM家族蛋白可通过提高宿主固有免疫应答或直接降解病毒蛋白发挥抗病毒活性；部分病毒有时也可利用TRIM家族蛋白调控细胞因子表达促进自身感染。本文综述了TRIM家族蛋白在病毒复制中的作用及相关机制的研究进展，为研究病毒感染机制提供参考。

关键词:三基序蛋白家族;E3泛素连接酶;脑心肌炎病毒;甲型流感病毒;乙型肝炎病毒

Abstract:

The tripartite motif (TRIM) protein family is composed of a variety of proteins with E3 ubiquitin ligase activity. These proteins are involved in different cell processes and play a role in the host immune response to viral infection. The proteins of TRIM family can exert antiviral activity by enhancing host innate immune response or directly degrading viral proteins. In some cases, some viruses can use TRIM family proteins to regulate cytokine expression to promote their infections. This article reviews the research progress in the role of TRIM family proteins in viral replication and the related mechanisms, aiming to provide a reference for studying the mechanism of viral infection.

Key words:tripartite motif;E3 ubiquitin ligase;encephalomyocarditis virus;influenza A virus;hepatitis B virus