细菌蛋白酶体及蛋白酶体抑制剂研究进展

Bacterial proteasomes and proteasome inhibitors

摘要:

蛋白酶体在真核生物、古菌和部分细菌(主要是放线菌)的胞内蛋白质降解中起着至关重要的作用。虽然三域生物蛋白酶体的结构相似，但细菌蛋白酶体在组装、调节、生理功能等方面与真核生物和古菌都截然不同。研究细菌蛋白酶体不仅有助于认识其起源和进化历程，也将为发掘蛋白酶体抑制剂(proteasome inhibitor, PI)这类具有广阔药用前景的化合物提供指导。本文综述了细菌蛋白酶体的结构、功能和进化假说，并概括了细菌蛋白酶体抑制剂的最新研究进展，期望为相关研究提供参考。

Abstract:

Proteasomes play a vital role in the intracellular proteolysis of eukaryotes, archaea, and some bacteria (mainly actinobacteria). Although similar in structure, bacterial proteasomes are distinguished from the eukaryotic and archaeal proteasomes in assembly, regulation, and physiological functions. Studying bacterial proteasomes helps understand their origin and evolutionary processes and guides the mining of proteasome inhibitors (PI) with broad medical application prospects. This review summarized the current research status of the structure, function, and evolution of bacterial proteasomes and the latest progress on bacterial proteasome inhibitors, hoping to provide references for related research.