嗜黏蛋白阿克曼氏菌治疗疾病的潜力与作用机制研究进展

Potential and mechanism of Akkermansia muciniphila in disease treatment

摘要:

嗜黏蛋白阿克曼氏菌(Akkermansia muciniphila, AKK)可促进肠道黏液分泌,维持肠道黏液动态平衡,调节肠黏膜屏障功能,在机体代谢调节、免疫应答中发挥重要作用。AKK对肠道炎症、神经炎症、机体代谢紊乱和癌症等疾病具有显著改善作用,被视为极具潜力的下一代益生菌。本文分别从消化系统、神经系统、代谢性紊乱和癌症等角度入手,系统概述AKK在疾病治疗中的潜力及作用分子机制。

关键词:嗜黏蛋白阿克曼氏菌;代谢异常;治疗潜力;作用机制

Abstract:

Akkermansia muciniphila (AKK) promotes the secretion, maintains the dynamic balance, and regulates the barrier function of intestinal mucus, playing a key role in metabolic regulation and immune response. As a promising next-generation probiotic, AKK can mitigate diseases such as intestinal inflammation, metabolic disorders, neuroinflammation, and cancers. We introduced the therapeutic potential of AKK for diseases of the digestive system, the nervous system, metabolic disorders and cancers, aiming to provide a systematic review of the potential role and molecular mechanism of AKK in disease treatment.

Key words:Akkermansia muciniphila;metabolic disorders;therapeutic potential;mechanism