细菌VI型分泌系统效应蛋白的装配及功能的研究进展

Advances in assembly mechanisms and functions of bacterial type VI secretion system effectors

摘要:

蛋白分泌作为细胞之间传递信号的途径之一,在微生物生存竞争中也扮演着重要的角色。革兰氏阴性菌可以通过VI型分泌系统(type VI secretion system, T6SS)将效应蛋白传递至胞外或原核和真核微生物中,从而介导微生物间的竞争或宿主-细菌的相互作用,最终建立竞争优势。本文主要总结了T6SS的结构与组成,并重点对效应蛋白的装配以及其与免疫蛋白的作用机制的研究进展进行阐述,为以后靶向T6SS抗菌药物的研制提供新思路。

Abstract:

Bacterial protein secretion is an important way of cell-cell interaction between species, which plays a crucial role in interbacterial competition and pathogenesis. Gram-negative bacteria could use the type VI secretion system (T6SS) to deliver effector proteins to the extracellular environment or prokaryotic and eukaryotic cells, thereby promoting their fitness during competition between microorganisms or host-microbe interactions. This paper summarizes the latest advances in the structures and components of T6SS, with focus on effector assembly and effector-immunity pairs, providing new strategies for the development of antibacterial drugs in the future.