乳杆菌胞外多糖合成基因簇及构效关系

Lactobacillus exopolysaccharide:gene clusters for synthesis and structure-activity relationship

摘要:

肠道菌群稳态对维护人体的健康具有至关重要的作用。作为肠道天然微生物群"守卫兵",益生菌参与改善体内微生态平衡。乳杆菌(Lactobacillus)是一种肠道益生菌的代表,其合成的胞外多糖(exopolysaccharide, EPS)既可通过增益肠道内其他益生菌的生长来优化肠道微生态,还具有抗肿瘤、抗氧化、降胆固醇、降血压和增强机体免疫力等益生功能。本文对近年来乳杆菌胞外多糖的遗传、生物学活性、构效关系等方面的研究进展,进行综述和展望。

Abstract:

Intestinal microflora homeostasis plays a crucial role in maintaining human health. As a guard of the natural intestinal microflora, probiotics improve the microecological balance in the host. Lactobacillus is a representative of intestinal probiotics. The exopolysaccharide (EPS) synthesized by Lactobacillus can optimize the intestinal microecology by promoting the growth of other probiotics in the intestine. Moreover, EPS is praised for anti-tumor, antioxidant, cholesterol-lowering, blood pressure-lowering, and immunity-enhancing activities. This article reviews the research progress in the genetics, biological activities, structure-activity relationship of Lactobacillus EPS in recent years.