2025年8月18日 周一
首页 > 过刊浏览>2023年第63卷第10期 >3711-3726. DOI:10.13343/j.cnki.wsxb.20230129
PDF HTML阅读 XML下载 导出引用 引用提醒
微生物降解玉米赤霉烯酮的研究进展
作者:
基金项目:

河南科技大学青年骨干教师培养计划（13450009）；国家自然科学基金（32072771）


Research progress in microbial degradation of zearalenone
Author:
  • ZHAO Tianxiang

    ZHAO Tianxiang

    Luoyang Key Laboratory of Live Carrier Biomaterial and Animal Disease Prevention and Control, Henan University of Science and Technology, Luoyang 471023, Henan, China;Laboratory of Functional Microbiology and Animal Health, College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471023, Henan, China
    在期刊界中查找
    在百度中查找
    在本站中查找
  • YU Zuhua

    YU Zuhua

    Luoyang Key Laboratory of Live Carrier Biomaterial and Animal Disease Prevention and Control, Henan University of Science and Technology, Luoyang 471023, Henan, China;Laboratory of Functional Microbiology and Animal Health, College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471023, Henan, China
    在期刊界中查找
    在百度中查找
    在本站中查找
  • DING Ke

    DING Ke

    Luoyang Key Laboratory of Live Carrier Biomaterial and Animal Disease Prevention and Control, Henan University of Science and Technology, Luoyang 471023, Henan, China;Laboratory of Functional Microbiology and Animal Health, College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471023, Henan, China
    在期刊界中查找
    在百度中查找
    在本站中查找
  • LIAO Chengshui

    LIAO Chengshui

    Luoyang Key Laboratory of Live Carrier Biomaterial and Animal Disease Prevention and Control, Henan University of Science and Technology, Luoyang 471023, Henan, China;Laboratory of Functional Microbiology and Animal Health, College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471023, Henan, China
    在期刊界中查找
    在百度中查找
    在本站中查找
  • 摘要
    • | |
  • 访问统计
    • |
  • 参考文献 [93]
    • |
  • 相似文献 [20]
    • | | |
  • 文章评论
    摘要:

    玉米赤霉烯酮（zearalenone，ZEN）是霉变谷物中常见的霉菌毒素之一，主要出现在霉变的玉米、小麦等谷物中，给畜禽和人类带来一定程度的健康危害，如生殖毒性、免疫毒性、肝毒性和肾毒性等。目前，解决玉米赤霉烯酮污染问题的方法包括物理、化学和生物3个途径。虽然传统的物理和化学脱毒方法已经运用在许多的饲料生产中，但同时也存在着二次污染的风险。生物降解法是一种利用微生物吸附和降解玉米赤霉烯酮的脱毒方法，具有安全环保、高效、特异性强和脱毒率高的特性，且不影响谷物的营养价值，已成为玉米赤霉烯酮降解研究的热点。本文主要介绍了近年来降解玉米赤霉烯酮的微生物种类，并将其归纳分类，从微生物的脱毒能力、脱毒方法和脱毒产物进行了叙述，综述了微生物脱毒的优点及前景，以期为微生物降解玉米赤霉烯酮的理论研究及实际应用提供新的视角。

    Abstract:

    Zearalenone (ZEN), one of the common mycotoxins in moldy grain crops such as maize and wheat, brings health hazards to domesticated animals and humans, demonstrating reproductive toxicity, immunotoxicity, hepatotoxicity, and nephrotoxicity. Physical, chemical, and biological methods have been used to address zearalenone contamination. The physical and chemical methods applied in feed production have a risk of secondary contamination. Biodegradation as a detoxification method using microbial adsorption and degradation of zearalenone is the characterized by high safety, environmental friendliness, high efficiency, specificity, and high detoxification rate and does not affect the nutritional value of grains. Therefore, biodegradation becomes a hot spot for the research on zearalenone degradation. This article mainly introduces the microbial species capable of degrading zearalenone from the detoxification capacity, methods, and products and summarizes the advantages and prospects of microbial detoxification, aiming to provide new perspectives for the theoretical research and practical application of microbial methods for degrading zearalenone.

    参考文献
    [1] 华洵璐, 张海涛, 董曼佳, 王红连, 严艺琳. 免疫亲和柱净化-高效液相色谱法测定饲料中玉米赤霉烯酮的不确定度评定[J]. 粮食与饲料工业, 2021(4):64-71. HUA XL, ZHANG HT, DONG MJ, WANG HL, YAN YL. Uncertainty evaluation for detecting zearalenone in feeds by immunoaffinity column clean-up and high per-formance liquid chromatography[J]. Cereal & Feed Industry, 2021(4):64-71(in Chinese).
    [2] 许玲涵. 饲料中常见霉菌毒素及防控措施[J]. 畜牧业环境, 2020(3):73. XU LH. Common fungal toxins and preventive measures in feed[J]. Animal Industry and Environment, 2020(3):73(in Chinese).
    [3] 雷元培, 周建川, 王利通, 郑文革, 赵丽红, 计成. 2018年中国饲料原料及配合饲料中霉菌毒素污染调查报告[J]. 饲料工业, 2020, 41(10):60-64. LEI YP, ZHOU JC, WANG LT, ZHENG WG, ZHAO LH, JI C. A survey report on the mycotoxin contamination of Chinese raw materials and feed in 2018[J]. Feed Industry, 2020, 41(10):60-64(in Chinese).
    [4] 周健庭, 郑和. 2021年饲料霉菌毒素污染情况调查报告[J]. 养猪, 2022(3):12-16. ZHOU JT, ZHENG H. Investigation report on mycotoxin pollution in feed in 2021[J]. Swine Production, 2022(3):12-16(in Chinese).
    [5] 么晓黎. 浅析真菌毒素与玉米质量安全的关系[J]. 现代畜牧科技, 2018(7):24. YAO XL. Analysis on the relationship between mycotoxins and corn quality and safety[J]. Modern Animal Husbandry Science & Technology, 2018(7):24(in Chinese).
    [6] 国家卫生和计划生育委员会, 国家食品药品监督管理总局. 食品安全国家标准食品中真菌毒素限量:GB 2761-2017[S]. 北京:中国标准出版社, 2017. National Health and Family Planning Commission, China Food and Drug Administration. Food safety national standard:fungi toxins in food:GB 2761-2017[S]. Beijing:Standards Press of China, 2017(in Chinese).
    [7] 周建川, 史东辉, 计成. 玉米赤霉烯酮和脱氧雪腐镰刀菌烯醇对动物毒性的研究进展[J]. 动物营养学报, 2020, 32(6):2460-2466 ZHOU JC, SHI DH, JI C. Research progress on toxicity of zearalenone and deoxynivalenol in animals[J]. Chinese Journal of Animal Nutrition, 2020, 32(6):2460-2466(in Chinese).
    [8] CAO HW, ZHI Y, XU HB, FANG HQ, JIA XD. Zearalenone causes embryotoxicity and induces oxidative stress and apoptosis in differentiated human embryonic stem cells[J]. Toxicology in Vitro, 2019, 54:243-250.
    [9] CAI PR, FENG NN, ZOU H, GU JH, LIU XZ, LIU ZP, YUAN Y, BIAN JC. Zearalenone damages the male reproductive system of rats by destroying testicular focal adhesion[J]. Environmental Toxicology, 2023, 38(2):278-288.
    [10] CAI GD, SUN K, WANG T, ZOU H, GU JH, YUAN Y, LIU XZ, LIU ZP, BIAN JC. Mechanism and effects of zearalenone on mouse T lymphocytes activation in vitro[J]. Ecotoxicology and Environmental Safety, 2018, 162:208-217.
    [11] BULGARU CV, ELIZA MARIN D, PISTOL GC, TARANU I. Zearalenone and the immune response[J]. Toxins, 2021, 13(4):248.
    [12] LIANG Z, REN ZH, GAO S, CHEN Y, YANG YY, YANG D, DENG JL, ZUO ZC, WANG Y, SHEN LH. Individual and combined effects of deoxynivalenol and zearalenone on mouse kidney[J]. Environmental Toxicology and Pharmacology, 2015, 40(3):686-691.
    [13] ZHANG CQ, LI CQY, LIU KC, ZHANG Y. Characterization of zearalenone-induced hepatotoxicity and its mechanisms by transcriptomics in zebrafish model[J]. Chemosphere, 2022, 309:136637.
    [14] PRZYBYLSKA-GORNOWICZ B, LEWCZUK B, PRUSIK M, HANUSZEWSKA M, PETRUSEWICZ-KOSIŃSKA M, GAJĘCKA M, ZIELONKA Ł, GAJĘCKI M. The effects of deoxynivalenol and zearalenone on the pig large intestine. A light and electron microscopy study[J]. Toxins, 2018, 10(4):148.
    [15] LO EKK, WANG XW, LEE PK, WONG HC, LEE JCY, GÓMEZ-GALLEGO C, ZHAO DY, EL-NEZAMI H, LI J. Mechanistic insights into zearalenone-accelerated colorectal cancer in mice using integrative multi-omics approaches[J]. Computational and Structural Biotechnology Journal, 2023, 21:1785-1796.
    [16] ZŁOCH M, ROGOWSKA A, POMASTOWSKI P, RAILEAN-PLUGARU V, WALCZAK-SKIERSKA J, RUDNICKA J, BUSZEWSKI B. Use of Lactobacillus paracasei strain for zearalenone binding and metabolization[J]. Toxicon, 2020, 181:9-18.
    [17] 邓桃, 袁青松, 周涛, 江维克, 肖承鸿, 杨昌贵, 郭兰萍. 中药材中玉米赤霉烯酮毒素污染现状及其脱毒研究进展[J]. 安徽农业科学, 2022, 50(16):5-9. DENG T, YUAN QS, ZHOU T, JIANG WK, XIAO CH, YANG CG, GUO LP. The present situation of ZEN pollution in Chinese medicinal materials and its research progress of detoxification[J]. Journal of Anhui Agricultural Sciences, 2022, 50(16):5-9(in Chinese).
    [18] 杨凡, 张俊楠, 王金全, 吕宗浩, 刘杰, 郑云朵. 霉菌毒素吸附剂对玉米赤霉烯酮脱毒效果的评价[J]. 动物营养学报, 2020, 32(5):2116-2125. YANG F, ZHANG JN, WANG JQ, LYU ZH, LIU J, ZHENG YD. Assessment on detoxification effects of mycotoxin adsorbent on zearalenone[J]. Chinese Journal of Animal Nutrition, 2020, 32(5):2116-2125(in Chinese).
    [19] 孔青, 翟翠萍, 林洪, 单世华. 粮油食品中黄曲霉毒素去除方法研究进展[J]. 粮食加工, 2011, 36(4):47-50. KONG Q, ZHAI CP, LIN H, SHAN SH. Research progress on the removal of aflatoxin in foods[J]. Grain Processing, 2011, 36(4):47-50(in Chinese).
    [20] CALADO T, ABRUNHOSA L, CABO VERDE S, ALTÉ L, VENÂNCIO A, FERNÁNDEZ-CRUZ ML. Effect of gamma-radiation on zearalenone-degradation, cytotoxicity and estrogenicity[J]. Foods, 2020, 9(11):1687.
    [21] YANG K, LI K, PAN LH, LUO XH, XING JL, WANG J, WANG L, WANG R, ZHAI YH, CHEN ZX. Effect of ozone and electron beam irradiation on degradation of zearalenone and ochratoxin A[J]. Toxins, 2020, 12(2):138.
    [22] KRIFATON C, KRISZT B, RISA A, SZOBOSZLAY S, CSERHÁTI M, HARKAI P, ELDRIDGE M, WANG J, KUKOLYA J. Application of a yeast estrogen reporter system for screening zearalenone degrading microbes[J]. Journal of Hazardous Materials, 2013, 244/245:429-435.
    [23] CSERHÁTI M, KRISZT B, KRIFATON C, SZOBOSZLAY S, HÁHN J, TÓTH S, NAGY I, KUKOLYA J. Mycotoxin-degradation profile of Rhodococcus strains[J]. International Journal of Food Microbiology, 2013, 166(1):176-185.
    [24] GARAI E, RISA A, VARGA E, CSERHÁTI M, KRISZT B, URBÁNYI B, CSENKI Z. Evaluation of the multimycotoxin-degrading efficiency of Rhodococcus erythropolis NI1 strain with the three-step zebrafish microinjection method[J]. International Journal of Molecular Sciences, 2021, 22(2):724.
    [25] KRISZT R, KRIFATON C, SZOBOSZLAY S, CSERHÁTI M, KRISZT B, KUKOLYA J, CZÉH Á, FEHÉR-TÓTH S, TÖRÖK L, SZŐKE Z, KOVÁCS KJ, BARNA T, FERENCZI S. A new zearalenone biodegradation strategy using non-pathogenic Rhodococcus pyridinivorans K408 strain[J]. Public Library of Science, 2012, 7(9):e43608.
    [26] ZHOU JC, AO X, LEI YP, JI C, MA QG. Bacillus subtilis ANSB01G culture alleviates oxidative stress and cell apoptosis induced by dietary zearalenone in first-parity gestation sows[J]. Animal Nutrition, 2020, 6(3):372-378.
    [27] SHI DH, ZHOU JC, ZHAO LH, RONG XP, FAN Y, HAMID H, LI WQ, JI C, MA QG. Alleviation of mycotoxin biodegradation agent on zearalenone and deoxynivalenol toxicosis in immature gilts[J].Journal of Animal Science and Biotechnology, 2018, 9:42.
    [28] GUO YP, HUO XT, ZHAO LH, MA QG, ZHANG JY, JI C, ZHAO LH. Protective effects of Bacillus subtilis ANSB060, Bacillus subtilis ANSB01G, and Devosia sp. ANSB714-based mycotoxin biodegradation agent on mice fed with naturally moldy diets[J]. Probiotics and Antimicrobial Proteins, 2020, 12(3):994-1001.
    [29] ZHANG JN, ZHENG YD, TAO H, LIU J, ZHAO P, YANG F, LV ZH, WANG JQ. Effects of Bacillus subtilis ZJ-2019-1 on Zearalenone toxicosis in female gilts[J]. Toxins, 2021, 13(11):788.
    [30] 段锦, 丁轲, 余祖华, 李旺, 李元晓, 何万领, 曹平华, 赵龙妹, 贾艳艳, 王玉琴, 刘宁. 玉米赤霉烯酮降解菌株的筛选及降解特性研究[J]. 动物营养学报, 2021, 33(9):5266-5276. DUAN J, DING K, YU ZH, LI W, LI YX, HE WL, CAO PH, ZHAO LM, JIA YY, WANG YQ, LIU N. Screening and degradation characteristics of strains degrading Zearalenone[J]. Chinese Journal of Animal Nutrition, 2021, 33(9):5266-5276(in Chinese).
    [31] YANG SB, ZHENG HC, XU JY, ZHAO XY, SHU WJ, LI XM, SONG H, MA YH. New biotransformation mode of Zearalenone identified in Bacillus subtilis Y816 revealing a novel ZEN conjugate[J]. Journal of Agricultural and Food Chemistry, 2021, 69(26):7409-7419.
    [32] WANG XL, BAI YG, HUANG HQ, TU T, WANG Y, WANG YR, LUO HY, YAO B, SU XY. Degradation of aflatoxin B1 and Zearalenone by bacterial and fungal laccases in presence of structurally defined chemicals and complex natural mediators[J]. Toxins, 2019, 11(10):609.
    [33] QIN X, SU XY, TU T, ZHANG J, WANG XL, WANG YR, WANG Y, BAI YG, YAO B, LUO HY, HUANG HQ. Enzymatic degradation of multiple major mycotoxins by dye-decolorizing peroxidase from Bacillus subtilis[J]. Toxins, 2021, 13(6):429.
    [34] 杜稳, 刘虎军, 王峻, 王浩宇, 孙长坡. 酸性条件下降解玉米赤霉烯酮菌株的分离鉴定和初步应用[J]. 粮油食品科技, 2018, 26(3):60-66. DU W, LIU HJ, WANG J, WANG HY, SUN CP. Isolation, identification and preliminary application of Zearalenone-degrading bacterium under acidic condition[J]. Science and Technology of Cereals, Oils and Foods, 2018, 26(3):60-66(in Chinese).
    [35] 魏单平, 刘玉洁, 孙向丽, 闫峰宾, 蒋瑞瑞, 康相涛, 王彦彬. 玉米赤霉烯酮降解菌的筛选及其活性检测[J]. 畜牧兽医学报, 2017, 48(4):761-768. WEI DP, LIU YJ, SUN XL, YAN FB, JIANG RR, KANG XT, WANG YB. Screening and activity detection of a bacterial strain degrading Zearalenone[J]. Acta Veterinaria et Zootechnica Sinica, 2017, 48(4):761-768(in Chinese).
    [36] XU LP, SUN XL, WAN XH, LI H, YAN FB, HAN RL, LI H, LI ZJ, TIAN YD, LIU XJ, KANG XT, WANG YB. Identification of a Bacillus amyloliquefaciens H6 thioesterase involved in Zearalenone detoxification by transcriptomic analysis[J]. Journal of Agricultural and Food Chemistry, 2020, 68(37):10071-10080.
    [37] 吴宗芮, 丁轲, 余祖华, 李旺, 李元晓, 曹平华, 何万领, 贾艳艳, 刘宁. 降解玉米赤霉烯酮菌株的筛选、降解机制及特性研究[J]. 中国粮油学报, 2022, 37(9):27-33. WU ZR, DING K, YU ZH, LI W, LI YX, CAO PH, HE WL, JIA YY, LIU N. Screening, degradation mechanism and characteristics of strains degrading Zearalenone[J]. Journal of the Chinese Cereals and Oils Association, 2022, 37(9):27-33(in Chinese).
    [38] 潘丽婷, 徐圣佳, 胡晓丹, 徐丽梅, 史建荣, 顾振新, 徐剑宏. 玉米赤霉烯酮降解菌的分离鉴定及其降解特性研究[J]. 中国粮油学报, 2018, 33(6); 113-119, 126. PAN LT, XU SJ, HU XD, XU LM, SHI JR, GU ZX, XU JH. Isolation, identification and its degradation characteristics of Zearalenone-degrading bacteria[J]. Journal of the Chinese Cereals and Oils Association, 2018, 33(6):113-119, 126(in Chinese).
    [39] AZAM MS, YU DZ, LIU N, WU AB. Degrading ochratoxin A and Zearalenone mycotoxins using a multifunctional recombinant enzyme[J]. Toxins, 2019, 11(5):301.
    [40] HANIF A, ZHANG F, LI PP, LI CC, XU YJ, ZUBAIR M, ZHANG MX, JIA DD, ZHAO XZ, LIANG JG, MAJID T, YAN J, FARZAND A, WU HJ, GU Q, GAO XW. Fengycin produced by Bacillus amyloliquefaciens FZB42 inhibits Fusarium graminearum growth and mycotoxins biosynthesis[J]. Toxins, 2019, 11(5):295.
    [41] WANG N, LI P, PAN JW, WANG MY, LONG M, ZANG J, YANG SH. Bacillus velezensis A2 fermentation exerts a protective effect on renal injury induced by Zearalenone in mice[J]. Scientific Reports, 2018, 8:13646.
    [42] GUO YP, ZHOU JC, TANG Y, MA QG, ZHANG JY, JI C, ZHAO LH. Characterization and genome analysis of a Zearalenone-degrading Bacillus velezensis strain ANSB01E[J]. Current Microbiology, 2020, 77(2):273-278.
    [43] FU GH, WANG LH, LI L, LIU J, LIU SZ, ZHAO X. Bacillus licheniformis CK1 alleviates the toxic effects of Zearalenone in feed on weaned female Tibetan piglets[J]. Journal of Animal Science, 2018, 96(10):4471-4480.
    [44] HSU TC, YI PJ, LEE TY, LIU JR. Probiotic characteristics and Zearalenone-removal ability of a Bacillus licheniformis strain[J]. Public Library of Science, 2018, 13(4):e0194866.
    [45] 葛婵婵, 熊犍, 赵晨, 汪洋, 申琳, 张晓琳. 降解玉米赤霉烯酮的芽孢杆菌筛选[J]. 粮油食品科技, 2015, 23(3):90-94. GE CC, XIONG J, ZHAO C, WANG Y, SHEN L, ZHANG XL. Screening of bacillus being able to degrade Zearalenone[J]. Science and Technology of Cereals, Oils and Foods, 2015, 23(3):90-94(in Chinese).
    [46] WANG Y, ZHANG J, WANG YL, WANG KR, WEI H, SHEN LX. Isolation and characterization of the Bacillus cereus BC7 strain, which is capable of Zearalenone removal and intestinal flora modulation in mice[J]. Toxicon, 2018, 155:9-20.
    [47] 余祖华, 丁轲, 刘赛宝, 李亚菲, 李旺, 李元晓, 曹平华, 刘一尘, 孙二刚. 一株降解呕吐毒素蜡样芽孢杆菌的筛选与鉴定[J]. 食品科学, 2016, 37(5):121-125. YU ZH, DING K, LIU SB, LI YF, LI W, LI YX, CAO PH, LIU YC, SUN EG. Screening and identification of a Bacillus cereus strain able to degradate deoxynivalenol[J]. Food Science, 2016, 37(5):121-125(in Chinese).
    [48] ZHU Y, DROUIN P, LEPP D, LI XZ, ZHU HH, CASTEX M, ZHOU T. A novel microbial Zearalenone transformation through phosphorylation[J]. Toxins, 2021, 13(5):294.
    [49] KRÓL A, POMASTOWSKI P, RAFIŃSKA K, RAILEAN-PLUGARU V, WALCZAK J, BUSZEWSKI B. Microbiology neutralization of Zearalenone using Lactococcus lactis and Bifidobacterium sp.[J]. Analytical and Bioanalytical Chemistry, 2018, 410(3):943-952.
    [50] ROGOWSKA A, POMASTOWSKI P, WALCZAK J, RAILEAN-PLUGARU V, RUDNICKA J, BUSZEWSKI B. Investigation of Zearalenone adsorption and biotransformation by microorganisms cultured under cellular stress conditions[J]. Toxins, 2019, 11(8):463.
    [51] ADUNPHATCHARAPHON S, PETCHKONGKAEW A, VISESSANGUAN W. In vitro mechanism assessment of Zearalenone removal by plant-derived Lactobacillus plantarum BCC 47723[J]. Toxins, 2021, 13(4):286.
    [52] BELGACEM H, BEN SALAH-ABBÈS J, EZZDINI K, A ABDEL-WAHHAB M, ZINEDINE A, ABBÈS S. Lactobacillus plantarum MON03 counteracts Zearalenone génotoxicty in mice:chromosome aberrations, micronuclei, DNA fragmentation and apoptotique gene expression[J]. Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 2019, 840:11-19.
    [53] VEGA MF, DIEGUEZ SN, RICCIO B, ARANGUREN S, GIORDANO A, DENZOIN L, SORACI AL, TAPIA MO, ROSS R, APÁS A, GONZÁLEZ SN. Zearalenone adsorption capacity of lactic acid bacteria isolated from pigs[J]. Brazilian Journal of Microbiology, 2017, 48(4):715-723.
    [54] 要强. 鼠李糖乳杆菌对3种常见霉菌毒素的脱毒作用及机制研究[J]. 饲料研究, 2019(11):75-79. YAO Q. Detoxification of Lactobacillus rhamnosus against three common mycotoxins and its mechanism[J]. Feed Research, 2019(11):75-79(in Chinese).
    [55] RAGOUBI C, QUINTIERI L, GRECO D, MEHREZ A, MAATOUK I, D'ASCANIO V, LANDOULSI A, AVANTAGGIATO G. Mycotoxin removal by Lactobacillus spp. and their application in animal liquid feed[J]. Toxins, 2021, 13(3):185.
    [56] 唐彧, 张琼琼, 郭永鹏, 郑雅文, 赵丽红. 一株同时降解玉米赤霉烯酮和黄曲霉毒素B1的谷氨酸棒状杆菌及其降解特性研究[J]. 饲料工业, 2019, 40(20):34-39. TANG Y, ZHANG QQ, GUO YP, ZHENG YW, ZHAO LH. Isolation of a corynebacterium glutamate capable of degrading of ZEN and AFB1, and investigation of its degrading characteristics[J]. Feed Industry, 2019, 40(20):34-39(in Chinese).
    [57] QIN X, XIN YZ, ZOU JH, SU XY, WANG XL, WANG YR, ZHANG J, TU T, YAO B, LUO HY, HUANG HQ. Efficient degradation of aflatoxin B1 and Zearalenone by laccase-like multicopper oxidase from Streptomyces thermocarboxydus in the presence of mediators[J]. Toxins, 2021, 13(11):754.
    [58] TAN H, HU YC, HE J, WU L, LIAO F, LUO B, HE YJ, ZUO ZC, REN ZH, ZHONG ZJ, PENG GN, DENG JL. Zearalenone degradation by two Pseudomonas strains from soil[J].Mycotoxin Research, 2014, 30(4):191-196.
    [59] HOUSHAYMI B, AWADA R, KEDEES M, SOAYFANE Z. Pyocyanin, a metabolite of Pseudomonas aeruginosa, exhibits antifungal drug activity through inhibition of a pleiotropic drug resistance subfamily FgABC3[J]. Drug Research, 2019, 69(12):658-664.
    [60] 王国兵, 伍松陵, 林爱军, 赵越, 常晓娇, 漆佳, 孙长坡. 玉米赤霉烯酮降解菌的分离及降解特性研究[J]. 中国粮油学报, 2019, 34(1):83-88. WANG GB, WU SL, LIN AJ, ZHAO Y, CHANG XJ, QI J, SUN CB. Isolation and degradation characteristics of zearalenone-degrading bacterium[J]. Journal of the Chinese Cereals and Oils Association, 2019, 34(1):83-88(in Chinese).
    [61] DENG T, YUAN QS, ZHOU T, GUO LP, JIANG WK, ZHOU SH, YANG CG, KANG CZ. Screening of zearalenone-degrading bacteria and analysis of degradation conditions[J]. Zhongguo Zhong Yao Za Zhi, 2021, 46(20):5240-5246.
    [62] TANG YQ, XIAO JM, CHEN Y, YU YG, XIAO XL, YU YS, WU H. Secretory expression and characterization of a novel peroxiredoxin for Zearalenone detoxification in Saccharomyces cerevisiae[J]. Microbiological Research, 2013, 168(1):6-11.
    [63] YU YS, WU H, TANG YQ, QIU LP. Cloning, expression of a peroxiredoxin gene from Acinetobacter sp. SM04 and characterization of its recombinant protein for Zearalenone detoxification[J]. Microbiological Research, 2012, 167(3):121-126.
    [64] TANG YQ, LIU CD, YANG JG, PENG X. A novel enzyme synthesized by Acinetobacter sp. SM04 is responsible for Zearalenone biodegradation[J]. Bioscience, Biotechnology, and Biochemistry, 2022, 86(2):209-216.
    [65] 金博文, 徐长春, 李根, 李晓宇, 王丽丽, 李纪彬, 徐永平. 玉米赤霉烯酮降解菌的分离、鉴定及其适宜降解条件的研究[J]. 中国畜牧兽医, 2020, 47(9):2808-2815. JIN BW, XU CC, LI G, LI XY, WANG LL, LI JB, XU YP. Isolation, identification and its suitable degradation conditions of a Zearalenone-degrading bacteria[J]. China Animal Husbandry & Veterinary Medicine, 2020, 47(9):2808-2815(in Chinese).
    [66] BRODEHL A, MÖLLER A, KUNTE HJ, KOCH M, MAUL R. Biotransformation of the mycotoxin Zearalenone by fungi of the genera Rhizopus and Aspergillus[J]. FEMS Microbiology Letters, 2014, 359(1):124-130.
    [67] SUN XL, HE XX, XUE KS, LI Y, XU D, QIAN H. Biological detoxification of Zearalenone by Aspergillus niger strain FS10[J]. Food and Chemical Toxicology, 2014, 72:76-82.
    [68] 于心蕊. 真菌毒素玉米赤霉烯酮降解酶基因资源挖掘及其催化效率分子改良研究[D]. 北京:中国农业科学院硕士学位论文. YU XR. Gene resource mining and improvement in catalytic efficiency of mycotoxin Zearalenone hydrolase[D]. Beijing:Master's Thesis of Chinese Academy of Agricultural Sciences (in Chinese).
    [69] TAKAHASHI-ANDO N, KIMURA M, KAKEYA H, OSADA H, YAMAGUCHI I. A novel lactonohydrolase responsible for the detoxification of Zearalenone:enzyme purification and gene cloning[J]. Biochemical Journal, 2002, 365(1):1-6.
    [70] ZHANG ZX, XU W, WU H, ZHANG WL, MU WM. Identification of a potent enzyme for the detoxification of Zearalenone[J]. Journal of Agricultural and Food Chemistry, 2020, 68(1):376-383.
    [71] KOSAWANG C, KARLSSON M, VÉLËZ H, RASMUSSEN PH, COLLINGE DB, JENSEN B, JENSEN DF. Zearalenone detoxification by Zearalenone hydrolase is important for the antagonistic ability of Clonostachys rosea against mycotoxigenic Fusarium graminearum[J]. Fungal Biology, 2014, 118(4):364-373.
    [72] YANG WC, HSU TC, CHENG KC, LIU JR. Expression of the Clonostachys rosea lactonohydrolase gene by Lactobacillus reuteri to increase its Zearalenone-removing ability[J]. Microbial Cell Factories, 2017, 16(1):69.
    [73] SHCHERBAKOVA L, ROZHKOVA A, OSIPOV D, ZOROV I, MIKITYUK O, STATSYUK N, SINITSYNA O, DZHAVAKHIYA V, SINITSYN A. Effective Zearalenone degradation in model solutions and infected wheat grain using a novel heterologous lactonohydrolase secreted by recombinantPenicillium canescens[J]. Toxins, 2020, 12(8):475.
    [74] 王相生, 孙亚宁, 阮崇美, 张全伟, 张勇, 胡骁飞. 玉米赤霉烯酮降解酶在枯草芽孢杆菌中的表达及其对母猪繁殖性能的影响[J]. 动物营养学报, 2017, 29(11):4019-4025 WANG XS, SUN YN, RUAN CM, ZHANG QW, ZHANG Y, HU XF. Expression of Zearalenone degrading enzyme in Bacillus subilis and its effects on reproductive performance of sows[J]. Chinese Journal of Animal Nutrition, 2017, 29(11):4019-4025(in Chinese).
    [75] SABATER-VILAR M, MALEKINEJAD H, SELMAN MHJ, DOELEN MAM, FINK-GREMMELS J. In vitro assessment of adsorbents aiming to prevent deoxynivalenol and Zearalenone mycotoxicoses[J]. Mycopathologia, 2007, 163(2):81-90.
    [76] YIANNIKOURIS A, KETTUNEN H, APAJALAHTI J, PENNALA E, MORAN CA. Comparison of the sequestering properties of yeast cell wall extract and hydrated sodium calcium aluminosilicate in threein vitro models accounting for the animal physiological bioavailability of Zearalenone[J]. Food Additives & Contaminants:Part A, 2013, 30(9):1641-1650.
    [77] ZHANG HY, DONG MJ, YANG QY, APALIYA MT, LI J, ZHANG XY. Biodegradation of Zearalenone by Saccharomyces cerevisiae:possible involvement of ZEN responsive proteins of the yeast[J]. Journal of Proteomics, 2016, 143:416-423.
    [78] XIA Y, QIU YY, WU ZF, CHENG QQ, HU XY, CUI XB, WANG ZP. Preparation of recombinant Kluyveromyces lactis agents for simultaneous degradation of two mycotoxins[J]. AMB Express, 2022, 12(1):1-8.
    [79] 邵春山, 余祖华, 廖成水, 贾艳艳, 李静, 魏颖, 李元晓, 曹平华, 何万领, 赵龙妹, 李旺, 丁轲. 一株毕赤酵母菌MC-1降解呕吐毒素、生物学特性及初步应用[J]. 中国饲料, 2023(3):37-43. SHAO CS, YU ZH, LIAO CS, JIA YY, LI J, WEI Y, LI YX, CAO PH, HE WL, ZHAO LM, LI W, DING K. Degradation of deoxynivalenol by a strain of Pichia pastoris MC-1, biological characteristics and preliminary application[J]. China Feed, 2023(3):37-43(in Chinese).
    [80] CHANG XJ, LIU HJ, SUN J, WANG J, ZHAO CC, ZHANG W, ZHANG J, SUN CP. Zearalenone removal from corn oil by an enzymatic strategy[J]. Toxins, 2020, 12(2):117.
    [81] 柴成梁, 常晓娇, 王楠希, 伍松陵, 孙长坡. 玉米赤霉烯酮降解酶基因mbZHD的原核表达及其降解毒素初步研究[J]. 中国粮油学报, 2017, 32(8):29-33, 38. CHAI CL, CHANG XJ, WANG NX, WU SL, SUN CP. Preliminary study on prokaryotic expression and its degradation activity of a new Zearalenone-degradation enzyme (mbZHD)[J]. Journal of the Chinese Cereals and Oils Association, 2017, 32(8):29-33, 38(in Chinese).
    [82] BI K, ZHANG W, XIAO ZZ, ZHANG DW. Characterization, expression and application of a Zearalenone degrading enzyme from Neurospora crassa[J]. AMB Express, 2018, 8(1):194.
    [83] 刘文婷, 梁爱玲, 刘卫东, 商娜, 郭瑞庭, 张同存, 郑迎迎. 来源于麦氏喙枝孢霉的玉米赤霉烯酮水解酶在毕赤酵母中的高效表达及活性分析[J]. 微生物学通报, 2020, 47(7):2012-2020. LIU WT, LIANG AL, LIU WD, SHANG N, GUO RT, ZHANG TC, ZHENG YY. High expression and characterization of a novel Zearalenone hydrolase from Rhinocladiella mackenziei in Pichia pastoris[J]. Microbiology China, 2020, 47(7):2012-2020(in Chinese).
    [84] LIU FX, MALAPHAN W, XING FG, YU B. Biodetoxification of fungal mycotoxins Zearalenone by engineered probiotic bacterium Lactobacillus reuteri with surface-displayed lactonohydrolase[J]. Applied Microbiology and Biotechnology, 2019, 103(21/22):8813-8824.
    [85] VARGA J, PÉTERI Z, TÁBORI K, TÉREN J, VÁGVÖLGYI C. Degradation of ochratoxin A and other mycotoxins by Rhizopus isolates[J]. International Journal of Food Microbiology, 2005, 99(3):321-328.
    [86] YU XR, TU T, LUO HY, HUANG HQ, SU XY, WANG Y, WANG YR, ZHANG J, BAI YG, YAO B. Biochemical characterization and mutational analysis of a lactone hydrolase from Phialophora americana[J]. Journal of Agricultural and Food Chemistry, 2020, 68(8):2570-2577.
    [87] TIAN Y, TAN YL, YAN Z, LIAO YC, CHEN J, de BOEVRE M, de SAEGER S, WU AB. Antagonistic and detoxification potentials of Trichoderma isolates for control of Zearalenone (ZEN) producing Fusarium graminearum[J]. Frontiers in Microbiology, 2018, 8:2710.
    [88] KIM SH, VUJANOVIC V. Biodegradation and biodetoxification of Fusarium mycotoxins by Sphaerodes mycoparasitica[J]. AMB Express, 2017, 7(1):145.
    [89] BŁASZCZYK L, BASIŃSKA-BARCZAK A, ĆWIEK-KUPCZYŃSKA H, GROMADZKA K, POPIEL D, STĘPIEŃ Ł. Suppressive effect of Trichoderma spp. on toxigenic Fusarium species[J]. Polish Journal of Microbiology, 2017, 66(1):85-100.
    [90] 张晨曦, Yawa Minnie Elodie Folly, 赵月菊, 刘阳. 解淀粉芽孢杆菌NS2降解玉米赤霉烯酮的研究[J]. 核农学报, 2020, 34(7):1507-1517. ZHANG CX, FOLLY YME, ZHAO YJ, LIU Y. Degradation effects of Bacillus amyloliquefaciens NS2 on Zearalenone[J]. Journal of Nuclear Agricultural Sciences, 2020, 34(7):1507-1517(in Chinese).
    [91] 李旺, 史敦胜, 丁轲, 曹平华, 赵龙妹. 黄曲霉毒素分解酶基因克隆及其在大肠杆菌中的融合表达[J]. 食品与机械, 2019, 35(7):26-30, 50. LI W, SHI DS, DING K, CAO PH, ZHAO LM. Cloning of aflatoxin-detofizyme gene and fusion expression in Escherichia coli[J]. Food & Machinery, 2019, 35(7):26-30, 50(in Chinese).
    [92] 张瑾, 余祖华, 丁轲, 李旺, 李元晓, 曹平华, 贾艳艳, 何万领, 赵龙妹, 廖成水. 黄曲霉毒素B1降解菌的筛选及生物学特性分析[J]. 食品与发酵工业, 2022, 48(14):175-180. ZHANG J, YU ZH, DING K, LI W, LI YX, CAO PH, JIA YY, HE WL, ZHAO LM, LIAO CS. Screening and biological characteristics analysis of biodegrading bacteria of aflatoxin B1[J]. Food and Fermentation Industries, 2022, 48(14):175-180(in Chinese).
    [93] WANG PD, CHEN SB, LIAO CS, JIA YY, LI J, SHANG K, CHEN J, CAO PH, LI W, LI YX, YU ZH, DING K. Probiotic properties of chicken-derived highly adherent lactic acid bacteria and inhibition of enteropathogenic bacteria in caco-2 cells[J]. Microorganisms, 2022, 10(12):2515.
    引证文献
    网友评论
    网友评论
    分享到微博
    发 布
引用本文

赵天祥,余祖华,丁轲,廖成水. 微生物降解玉米赤霉烯酮的研究进展[J]. 微生物学报, 2023, 63(10): 3711-3726

复制
分享
文章指标
  • 点击次数:671
  • 下载次数: 1041
  • HTML阅读次数: 1372
  • 引用次数: 0
历史
  • 收稿日期:2023-03-03
  • 最后修改日期:2023-06-02
  • 在线发布日期: 2023-10-09
  • 出版日期: 2023-10-04
文章二维码

科微学术

微生物学报

您是本站第 6430921 访问者

通信地址：北京市朝阳区北辰西路1号院3号 中国科学院微生物研究所   邮编：100101

电话：010-64807516    E-mail：actamicro@im.ac.cn

版权所有：微生物学报 ® 2025 版权所有