Abstract:Staphylococcus aureus is considered as one of the most common foodborne pathogens causing infectious diseases in human and animals results in skin, soft tissue, and blood the infections, leading to sepsis and toxic shock syndrome. The overuse of antibiotics improves antibiotic resistance of S. aureus, leading to the emergence of methicillin-resistant S. aureus (MRSA), which has spread globally and seriously threatens the public health. Therefore, it is an urgent need to search for new therapies to effectively control S. aureus infection. This review focuses on the research progress in the prevention and treatment of S. aureus and makes an outlook on the controlling prospects, to provide theoretical guidance for the control of Staphylococcus aureus, especially MRSA.