Abstract:Electromagnetic radiation is a widespread physical phenomenon and exerts complex and profound effects on microorganisms. Understanding the state and function changes of microorganisms exposed to radiation is helpful to reveal the environmental response mechanisms of microorganisms and discover potential risk factors that threaten human health. By reviewing the relevant articles, we first discuss the damage of different types of electromagnetic radiation, including microwave, infrared, ultraviolet, X-rays, and γ-rays, to microorganisms. Furthermore, we elaborate on the molecular mechanisms by which electromagnetic radiation damages microorganisms from multi-omics. Finally, we reveal the potential relationship between the changes in the microbiome composition and the development of diseases in humans exposed to electromagnetic radiation.