肠道菌群与帕金森病关系的研究进展

Research progress in the relationship between gut microbiota and Parkinson's disease

摘要:

帕金森病是一种常见的神经退行性疾病，严重威胁着中老年人的健康，然而目前帕金森病的发病机制尚不完全明确。近年的研究显示，肠道菌群在帕金森病的发生发展中发挥重要角色，肠道菌群及其代谢物通过微生物-肠-脑轴影响机体的肠道黏膜屏障、神经炎症、内分泌等方面进而参与到帕金森病的发生发展中。肠道菌群可通过补充益生菌、粪菌移植、饮食调整、中医药干预等多种途径进行调控，是帕金森病防治的重要靶点。本文对肠道菌群在帕金森病中的可能发病机制进行综述，并进一步探讨肠道菌群失调的防治现状。

Abstract:

Parkinson's disease is a common neurodegenerative disorder that seriously threatens the health of middle-aged and elderly individuals.However,the pathogenesis of Parkinson's disease is not fully understood.Recent studies have shown that gut microbiota plays an important role in the occurrence and development of Parkinson's disease.Gut microbiota and its metabolites influence the intestinal mucosal barrier,neuroinflammation,endocrine system,and other aspects through the microbiota-gut-brain axis,thereby participating in the occurrence and development of Parkinson's disease.Gut microbiota can be regulated by various methods such as probiotic supplementation,fecal microbiota transplantation,dietary adjustments,and traditional Chinese medicine interventions,being an important target for the prevention and treatment of Parkinson's disease.This article reviews the possible mechanisms of gut microbiota being involved in the occurrence of Parkinson's disease and further discusses the current status of prevention and treatment of gut microbiota dysbiosis.