益生菌的精准筛选与应用

Precise screening and applications of probiotics

摘要:

益生菌是指当摄取足够数量时，对宿主健康有益的活的微生物，其有益作用已被广泛认证，但益生菌的益生功能具有菌株特异性。随着越来越多的新技术被引入到益生菌的研究中，根据个性化需求筛选具备特定功能的益生菌，成为当前益生菌的研究热点。传统的益生菌筛选方法存在一定的局限性，无法满足当前对精准医疗的需求。因此，基于表型、基因分型和靶标，自下而上的益生菌精准筛选策略具有重要的现实意义。本文旨在从基于表型、基因分型和靶标等3个方面，探讨益生菌精准筛选的理论基础、方法和技术，并且深入探讨益生菌的应用、安全性评价，以期为益生菌的精准筛选提供参考。

Abstract:

Probiotics refer to live microorganisms that are beneficial to the health of the host when ingested in sufficient quantities, and their beneficial effects have been widely recognized. However, the probiotic function of probiotics is strain-specific. As more and more emerging technologies are introduced into the research on probiotics, the screening of probiotics with specific functions according to individual needs has become a research hotspot. Conventional probiotic screening methods have limitations and cannot meet the current demand for precision medicine. Therefore, a bottom-up precision screening strategy for probiotics based on phenotyping, genotyping, and target is of great practical significance. This article discusses the theoretical basis, methods, and technologies of accurate screening of probiotics from phenotype, genotyping, and target, and the application and safety evaluation of probiotics, aiming to provide reference for the accurate screening of probiotics.