酿酒酵母高级醇代谢的转录调控研究进展

Transcriptional regulation of higher alcohol metabolism in Saccharomyces cerevisiae

摘要:

高级醇是酿酒酵母在葡萄酒酿造过程中产生的主要代谢副产物，其代谢受到多层次调控体系的精细调节。酿酒酵母高级醇代谢途径中的酶系及其编码基因已基本明确，但酿酒酵母高级醇代谢的转录调控机制仍不清晰。本文在总结酵母高级醇代谢途径及其代谢调控策略的基础上，重点综述了参与酵母高级醇代谢调控的转录因子Aro80p、GATA和Leu3p及其作用机制。旨在为系统理解酵母高级醇代谢转录调控机制，以及选育高级醇产量适中的酵母菌种提供理论参考。

Abstract:

Higher alcohols, major metabolic byproducts produced by Saccharomyces cerevisiae during winemaking, are intricately regulated by a multilevel system. While the enzymatic machinery and their encoding genes involved in the metabolic pathways of higher alcohols in S. cerevisiae have been largely elucidated, the transcriptional regulation underlying this process remains poorly understood. This paper, building upon a summary of the metabolic pathways and regulatory strategies of higher alcohols metabolism in yeast, focuses on the transcription factors Aro80p, GATA and Leu3p implicated in the regulation of higher alcohols metabolism in yeast and their mechanisms of action. The review aims to give theoretical insights into a comprehensive understanding of the transcriptional regulation of higher alcohols metabolism in yeast and facilitate the breeding of yeast strains with moderate production of higher alcohols.