植物病原真菌环磷酸腺苷信号通路研究进展

Research progress of cAMP signaling pathway in phytopathogenic fungi

摘要:

环磷酸腺苷(cyclic adenosine monophosphate, cAMP)是广泛存在于真核生物中的第二信使，其由腺苷酸环化酶(adenylate cyclase, AC)合成后，通过结合蛋白激酶A (protein kinase A, PKA)调控下游蛋白活性，从而参与植物病原真菌的生长发育、致病性(或致病力)、细胞壁完整性、环境胁迫响应及有性/无性生殖等方面的调控。本文介绍了植物病原真菌cAMP信号通路的信号转导及其与细胞中其他信号通路之间的交叉调控的相关研究进展，同时阐述了cAMP信号通路在植物病原真菌侵染过程中的重要作用。为今后以cAMP信号通路相关基因或蛋白作为靶点筛选抑制植物病原真菌的药物，以及利用cAMP信号通路对植物病原真菌生长发育及致病等相关调控机制进行病害防控提供了新的策略和思路。

Abstract:

Cyclic adenosine monophosphate (cAMP) is a second messenger widely present in eukaryotes. It is synthesized by adenylate cyclase (AC) and regulates downstream protein activity by binding to protein kinase A, thereby regulating fungal growth and development, virulence, cell wall integrity, environmental stress responses, and sexual/asexual reproduction. This article introduces the research progress of the cAMP signaling pathway in phytopathogenic fungi and the cooperation of this pathway with other signaling pathways in regulating cellular processes. At the same time, it elucidates the role of the cAMP signaling pathway in the infection of plant phytopathogenic fungi. This review is expected to provide reference for screening the agents for inhibiting phytopathogenic fungi that target the genes or proteins in the cAMP pathway. Additionally, the cAMP signaling pathway could be targeted to prevent and control the growth, development, and pathogenicity of phytopathogenic fungi in the future.