副溶血弧菌的Ⅲ型分泌系统

Type Ⅲ secretion system of Vibrio parahaemolyticus-A review

摘要:

摘要：副溶血弧菌是一种嗜盐性革兰氏阴性短杆菌，主要引起食物中毒性肠胃炎，还可引起水生动物疾病。除了耐热直接溶血毒素和耐热直接溶血相关毒素外，近年发现的副溶血弧菌两套Ⅲ型分泌系统也与该菌的致病性密切相关。Ⅲ型分泌系统1位于染色体1上，主要贡献对宿主细胞的细胞毒性，介导宿主细胞的自体吞噬作用，最后导致细胞死亡。Ⅲ型分泌系统2位于位于染色体2的毒力岛上，具有肠毒性。本文扼要介绍副溶血弧菌Ⅲ型分泌系统的组成、功能及相关转录调控机制。

关键词:关键词：副溶血弧菌，Ⅲ型分泌系统，致病性

Abstract:

Abstract: Vibrio parahaemolyticus is a halophilic gram-negative bacterium that causes food borne acute gastroenteritis in human being or certain diseases in aquatic species. In addition to thermostable direct hemolysin (tdh) and tdh-related hemolysin (trh), two sets of type III secretion systems (T3SS) were recently found to be associated closely with virulence. T3SS1 located on chromosome 1 is involved in cytotoxicity to host cells and orchestrates a multifaceted host cell infection by induction of autophagy, cell rounding, and eventual cell lysis. T3SS2 in chromosome 2 is enterotoxic. In this we address the composition of the two T3SS, their functions and regulation in Vibrio parahaemolyticus.

Key words:Keyword: Vibrio parahaemolyticus; type III secretion system; Pathogenicity