群体感应及其在动物病原菌致病中的作用

amongAnimal-associated Pathogens-a review

摘要:

摘要: 群体感应是指微生物群体某些基因的表达受到与群体密度相关的信号分子调控的现象。微生物以酰基高丝氨酸内酯化合物，某些短肽分子，呋喃酮类化合物，以及一些小分子物质为信号分子,介导不同的群体感应系统。各群体感应系统之间以平行协同或层次串连的方式组织起来调控微生物各种基因。众多病原菌致病基因的表达与群体感应密切相关，主要表现在：群体感应帮助微生物对宿主的侵袭和定殖；调控毒力因子的产生和作用于宿主；以及介导病原菌对宿主的免疫能力和药物抗性。进行群体感应对微生物致病过程调控的研究，将有利于从群体感应入手进行病原菌防控新策略的探索。

Abstract:

Abstract: Quorum sensing (QS) is a phenomenon that microbes regulate some of their genes by signals related to the density of population. It is confirmed that acyl-homoserine lactones (AHL), some peptides, some furanones and some other small moleculars can be used as quorum-sensing signals by microbes. Microbes control their physiology with different QS systems in parallel or hierarchical ways. A lot of microbial pathogenesis connect with quorum sensing closely. More and more studies show that QS systems regulate in microbial pathogenesis through the following points: (1) QS helping pathogens invasion and colonization; (2) QS regulating production of virulent factor; (3) QS giving pathogens the ability of immunity or drug resistance. We review the role of QS in microbial pathogenesis and address a new way to prevent and control microbial diseases.