噬菌体裂解酶的抗菌特性

Bacteriophage lysins: progress and perspective - A Review

摘要:

摘要：噬菌体裂解酶是一类细胞壁水解酶，可水解肽聚糖，造成细菌的破裂。裂解酶一般具有两到三个结构域，参与对底物的催化和结合。作为一种新型的杀菌制剂，裂解酶已被越来越多地应用于化脓链球菌、肺炎链球菌、金黄色葡萄球菌等革兰氏阳性细菌病的治疗。与抗生素治疗相比，裂解酶不易使细菌产生抗性且作用相对专一，这可能是解决现在日趋严重的细菌耐药性的一种可行方法。另外，裂解酶还具有高效性，作用协同性，且自身抗体不削弱其作用等优势，使之成为未来预防、控制致病菌一种可能的新途径。

Abstract:

Abstract: Phage endolysin targets the integrate cell wall and attack bonds in the peptidoglycan, resulting in degradation of bacteria. It features two or three domain structures, involving one or two catalytic domains and one binding domain. Endolysin is a promising antibiotic agent against gram-positive bacteria pathogen, such as Streptococcus pneumonia, Streptococcus pyogenes and Staphylococcus aureus. Compared to antibiotics, it is more specific and tested bacteria show no resistance to lysin. Therefore, it's a feasible measure for solving drug resistant problem. Beyond this, it is highly active and rapid lysis efficiency and has synergy effect when used together or with other antibiotics. Antibody against endolysin will not neutralize its activity. So endolysin treatment may be a new approach for preventing and controlling of bacteria pathogen.