白念珠菌RIM101途径与环境pH的应答反应

The response to environmental pH of RIM101 pathway in Candida albicans

摘要:

白念珠菌(Candida albicans)是一种重要条件致病菌,近年来引起人们的关注,大量的研究由此展开。对环境的改变积极做出应答是白念珠菌致病的重要条件。外界环境尤其是pH的变化影响着白念珠菌的形态和毒力。RIM101途经是真菌中一种保守的信号转导途径,白念珠菌也存在RIM101途经,并且该途径至少部分地控制着细胞对pH的应答。这里主要综述了近年来有关白念珠菌RIM101途径、pH应答及两者相互关系的研究。

Abstract:

Candida albicans is the most common kind of human opportunistic pathogen and gets many attentions in recent years. A lot of research has been done. The sites this organism colonizes differ in pH. C. albicans must be able to response to the environmental changes for its survival and pathogenicity. Extracellular environment, especially pH changes，is critical for C. albicans morphological differentiation and virulence. RIM101 pathway is a conserved fungal signal transduction pathway and at least partly controls the cellular pH response through the activity of the zinc finger transcription factor Rim101p. This review concisely summarized recent research on RIM101 pathway, pH response and their relationship in C. albicans.