内生真菌发酵生产紫杉醇的研究现状与展望

Recent advance and prospect on taxol production by endophytic fungus fermentation – A Review

摘要:

抗癌药物紫杉醇已在临床上广泛应用, 但受原料红豆杉树木短缺的制约, 存在巨大的供需差距, 而内生真菌发酵生产紫杉醇是解决紫杉醇药源问题的很有前景的途径之一。结合课题组多年来开展的科学试验研究工作, 概述了内生真菌发酵生产紫杉醇的优势、产紫杉醇内生真菌的分离研究现状和生物多样性及提高内生真菌生物合成紫杉醇量的途径。

Abstract:

Taxol has become a widely used clinical anti-cancer drug. Due to the scaricity of Taxus trees, current taxol output cannot meet the requirement of the market. Taxol produced by endophytic fungus fermentation has high prospective. We reviewed advantages of taxol production by fungus fermentation, research advances of isolation, biodiversity of taxol-producing fungi and methods of improved taxol output by endophytic fungus fermentation.