细菌芽胞—— 一种新型的疫苗载体

Bacterial spore - a new vaccine vehicle—A Review

摘要:

杆菌属的芽胞作为益生菌已经应用于人和动物的食品生产和细菌疗法。目前, 芽胞作为一种新型的疫苗载体, 开始用于破伤风、炭疽等疫苗的研究。与目前的第二代疫苗相比, 细菌芽胞热稳定性好, 遗传操作方便, 是一种理想的疫苗载体。本文就其作为疫苗载体的相关研究进行综述。

Abstract:

Bacterial spores are robust and dormant life forms with formidable resistance properties. Spores of the genus Bacillus have been used for a long time as probiotics for oral bacteriotherapy both in humans and animals. Recently, genetically modified B. subtilis spores and B. anthracis spores have been used as indestructible delivery vehicles for vaccine antigens. They were used as vaccine vehicles or spore vaccine for oral immunization against tetanus and anthrax, and the results were very exciting. Unlike many second generation vaccine systems currently under development, bacterial spores offer heat stability and the flexibility for genetic manipulation. At the same time, they can elicit mucosal immune response by oral and nasal administration. This review focuses on the use of recombinant spores as vaccine delivery vehicles.