铜绿假单胞菌Ⅲ型分泌系统的分子调控机制

Molecular determinants in regulating Pseudomonas aeruginosa typeⅢsecretion system—— A review

摘要:

铜绿假单胞菌是临床上重要的革兰氏阴性条件致病菌。通过Ⅲ型分泌系统，铜绿假单胞菌将其毒力因子注入到真核宿主细胞内部，逃避宿主巨噬细胞的吞噬降解，引起宿主相应的病理变化，是铜绿假单胞菌感染致病的重要原因。本文在简单介绍铜绿假单胞菌Ⅲ型分泌系统组成和功能的基础上，主要对调控T3SS基因转录表达的分子机制的研究进展进行综述和讨论。

Abstract:

Pseudomonas aeruginosa is a Gram-negative opportunistic bacterial pathogen. Successful injection of virulence factors into host cells, evasion of phagocytosis and promotion of pathogenesis depend primarily on the function of type III secretion system (T3SS). A complex set of signaling pathways have been shown to modulate T3SS expression. In this review, a brief introduction is given on the composition, function, and molecular determinants that regulate P. aeruginosa T3SS gene expression.