细菌抗氧化系统-oxyR调节子研究进展

Progress in oxyR regulon- the bacterial antioxidant defense system—— A review

摘要:

摘要：细菌抗氧化系统是细菌抵抗呼吸作用及环境因素导致的氧化损伤的一套防卫系统。oxyR调节子是最早发现的具有抗氧化作用的系统之一，由OxyR调节蛋白的编码基因oxyR及其调控的基因和操纵子所构成。oxyR调节子参与了细菌的抗氧化作用、抑制自发突变、致病性、铁代谢及外膜蛋白相变等多种生理代谢作用，这些发现促进了该调节子在细菌耐药性以及致突变物质筛查等方面的研究应用。作者主要从细菌oxyR调节子的结构组成、参与的生理代谢作用、OxyR调控转录的分子机制及影响因素等方面结合最新研究成果展开了介绍，以期对开展细菌抗药性研究及致突变物质的筛查等提供参考。

Abstract:

Abstract: The bacterial antioxidant defense system, including oxyR; soxRS; perR and ohrR, is employed to cope with oxidative stress induced by respiration or environmental assaults. oxyR, encompasses the gene encoding OxyR and some other genes and operons regulated by it, has captured the highest attention among these regulons. To date, members of oxyR regulon have been confirmed to participate in many physiological processes including antioxidant defense, repression of spontaneous mutagenesis, virulence, iron metabolism and out membrane protein phase-variation. Though controversy still exists among researchers, molecular mechanism of transcription regulation by OxyR has been intensively investigated in Escherichia coli. The diverse physiological processes participated by oxyR regulon have facilitated its applied research, such as screening for mutagens and dealing with antimicrobial resistance problems frequently occurring in industrial plants. This paper reviewed the recent progress of oxyR regulon, focusing on members regulated; physiological processes participated; mechanics and factors affected its transcription regulation activity, in order to bring some insights to further investigation of antimicrobial resistance and mutagens screening.