胸膜肺炎放线杆菌RTX毒素与宿主的相互作用
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国家十一五科技支撑计划(2006BAD06A12);国家自然科学基金(30530590)


The interaction between Actinobacillus pleuropneumoniae RTX toxin and host--A Review
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Supported by the 11th-five scientific and technology project of the Science and Technology Ministry of China (2006BAD06A12) and by the key grant of Natural Science Foundation of China (30530590)

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    摘要:

    摘要:胸膜肺炎放线杆菌引起猪传染性胸膜肺炎,给养猪业造成严重的经济损失。RTX毒素是胸膜肺炎放线杆菌主要的毒力因子,在该病原的感染与免疫中发挥“双刃剑”的作用。本文综述了近十多年来国内外在胸膜肺炎放线杆菌RTX毒素的研究进展,提出了毒素与宿主互作研究的必要性和技术可行性,认为毒素与宿主相互作用研究将诠释此病原的分子致病机理。

    Abstract:

    Abstract: Actinobacillus pleuropneumoniae (App) is the etiological agent of porcine pleuropneumonia which causes huge economic losses to the pig industry. RTX (repeat in the structural toxin,RTX ) is the main virulence-associated factor of the pathogen and, as a double blade sword, plays a dual role on the pathogen’s infection and immunity. The recently research progress that has been made within around ten years is updated in this paper and the necessity and techniques to initiate the pathogen-host interaction study is also raised and discussed. It is believed that the research on the interaction between host and App RTX may further elucidate the pathogen’s molecular pathogenesis.

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范盛先,刘辉,陈杨,陈焕春,何启盖. 胸膜肺炎放线杆菌RTX毒素与宿主的相互作用[J]. 微生物学报, 2009, 49(2): 141-146

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  • 收稿日期:2008-07-27
  • 最后修改日期:2008-09-30
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