条件致病真菌新型隐球酵母（Cryptococcus neoformans）致病性研究进展

Pathogenicity of the opportunistic pathogenic fungus Cryptococcus neoformans-A review

摘要:

摘要：真菌感染引起的疾病在临床上呈现较快的上升趋势，在国际上引起了广泛的重视。新型隐球酵母是主要病原真菌之一。过去十余年，对其致病的分子生物学研究有了较大的进展。重要致病因子（virulence factors）的合成调控及致病过程中信号传导途径等研究进展较快，这些都可能成为治疗甚至预防该真菌的焦点。本文在简要介绍致病因子的基础上，详细综述了分子生物学研究的进展情况。

Abstract:

Abstract: The increase of clinical fungal infection causes a wide awareness. Cryptococcus neoformans is one of the major fungal pathogens. In the past 10 years, much progress has been made in its molecular biological research, including the synthesis and mobilization of the virulence factors as well as the signal transduction pathways during pathogeny. All these will help prevent or treat this fungus. We review the virulence factors and the molecular biological research progress.