生物酶法合成L-精氨酸衍生物的研究进展

Enzymatic production of arginine derivatives: a review

摘要:

L-精氨酸是一种碱性氨基酸，具有多样化的官能团，是合成多种有用化合物的前体，其衍生物广泛应用于医疗、食品和化妆品等领域。L-精氨酸衍生物的合成方法有化学法、发酵法和酶法。在当前绿色经济和可持续发展的背景下，对比各种生产方法，生物酶法合成L-精氨酸衍生物具有明显优势。因此本文重点介绍了L-精氨酸衍生化的典型产品和合成技术，并介绍了生物酶法合成L-精氨酸衍生物未来可能的发展方向。

关键词:生物酶法，L-精氨酸，衍生化反应，鸟氨酸，瓜氨酸，胍基丁胺

Abstract:

L-arginine (L-Arg) is an alkaline amino acid that possesses various function groups and acts as an important precursor for useful chemical synthesis. L-Arg derivatives are widely applied in pharmaceutical, food and cosmetic industries. Environment friendly and cost-effective production of L-Arg derivatives by enzymatic catalysis provides significant advantages over chemical synthesis and microbial fermentation. In this article, several typical L-Arg derivatives and their enzymatic production processes are highlighted. Furthermore, prospect is also addressed about enzymatic production of L-Arg derivatives.

Key words:enzymatic production, L-arginine, derivatization, ornithine, citrulline, agmatine