细菌纳米磁小体有望作为靶向药物载体

The Magnetosomes of Magnetotactic Bacteria May be Used as Drug-carriers for Targeted Therapy

摘要:

趋磁细菌细胞内合成的纳米磁小体具有颗粒均匀,晶型稳定的特点,每个磁小体有脂膜包被。提纯的磁小体毒性低,生物相容性好,可作为多种药物和大分子化合物的载体而应用于定向治疗肿瘤。本文介绍了细菌磁小体的结构特点,提出了采用细菌磁小体连接抗癌药物的策略,讨论了建立磁小体载药体系靶向治疗癌症的可能性。

关键词:趋磁细菌; 磁小体; 纳米载体

Abstract:

Magnetotactic bacteria can form uniform nanometer sized magnetic particles(megnetosomes)within the bacterial cells and each particle is enveloped in a membrane.The purified magnetosomes are compatible and less toxic to SD rat.It may be used as a carrier to link with certain antibiotics and larger molecular compounds for treatment of tumors.Here we described the properties of the magnetosnmes and the strategies for linking drugs.We also discussed the possibility to establish the system of targeted therapy for cancers using drug-loaded magnetosumes.

Key words:Magnetotactic bacteria; Magnetosome; Nano-carrier