抗菌肽耐药性研究进展

Mechanism of antimicrobial peptide resistance

摘要:

抗菌肽是生物体产生的一类具有抵抗外源性病原体功能的小分子多肽, 具有抗细菌、真菌、病毒、癌细胞等多种活性。近几年的研究发现细菌会对抗菌肽产生耐药性。本文就细菌的构成性耐药性机制和诱导性耐药性机制等研究进展进行综述。

关键词:抗菌肽, 构成机制, 诱导机制, 耐药性

Abstract:

Antimicrobial peptides are a class of small peptides with anti-extrogenous pathogen activities. They are derived from organism and possess antibacterial, antifungus, antiviruses and anticancer cell actions. In recent years, it’s found that some microbial pathogens are able to resist antimicrobial peptides. The constitutive and inducible mechanism of a pathogen resists a given peptide were reviewed in this paper.

Key words:Antimicrobial peptides, Constitutive mechanism, Inducible mechanism, Resistance