1. The College of Life Sciences, Central China Normal University, Wuhan, Hubei 430079, China; 2. Key Laboratory of Pesti-cide and Chemical Biology, Ministry of Education, Central China Normal University, Wuhan, Hubei 430079, China 在期刊界中查找 在百度中查找 在本站中查找
1. The College of Life Sciences, Central China Normal University, Wuhan, Hubei 430079, China; 2. Key Laboratory of Pesti-cide and Chemical Biology, Ministry of Education, Central China Normal University, Wuhan, Hubei 430079, China 在期刊界中查找 在百度中查找 在本站中查找
A vast number of secondary metabolites are produced in Streptomycetes under the tight control by many regulators, including two-component regulatory systems. Two-component regulatory systems with high diversity are widely distributed in Streptomycetes and perform positive or negative regulation by different and complex modes during secondary metabolites biosynthesis. Here, we reviewed some research advances on these systems involved in secondary metabolites accumulation in streptomycetes, mainly focusing on the clarification of their action modes. We also prospected the research trends in this field and application of two-component regulatory systems in the metabolic engineering of natural products.
