常见食源性致病菌代谢组学研究进展

Advances in metabolomics of common food-borne pathogen

摘要:

食源性致病菌是一类以食品为传播媒介，可引起食物中毒的致病性微生物，是目前食源性疾病的主要诱因。食源性致病菌代谢组学通过研究致病菌代谢小分子物质产生的规律性和特征性，寻找新的检测靶标和建立基于代谢组学方法的食源性致病菌鉴别技术。随着目前代谢组学研究技术逐渐成熟和微生物挥发性代谢产物数据库的建立，食源性致病菌挥发性代谢产物分析已被建议作为临床和食品中致病菌鉴别的替代方法。本文综述了目前常见食源性致病菌代谢组学主要研究技术及其在临床和食品检测中的研究进展，以期为进一步建立食源性致病菌代谢产物数据库和研发基于代谢组学方法的食源性致病菌检测技术提供参考。

关键词:食源性致病菌，代谢组学，检测，生物标志分子，数据库

Abstract:

As inducement causes of food-borne diseases，the common food-borne pathogens are the pathogenic microorganism spreaded by food which usually cause food poisoning. Metabolomics of food-borne pathogen were to study the regularity and characteristic of the pathogenic bacterial small molecule metabolisms, then to look for new detection targets and establish the food-borne pathogen identification technology based on metabolomics method. The analysis of foodborne pathogens volatile metabolites has been proposed as an alternative method for the identification of pathogens in food as the current metabolomics technology matures and existing microbial volatile metabolites database. This paper reviewed the metabolomics of common food-borne pathogen research technology and its research progress in clinical and food detection, simultaneously highlighted its broad application prospect.

Key words:Food-borne Pathogen, Metabolomics, Detection, Biomarkers, Database