海洋放线菌Marinactinospora thermotolerans的研究进展

Advances in marine actinomycetes of Marinactinospora thermotolerans

摘要:

海洋放线菌以产生多种活性天然产物而著称，其中部分结构新颖的活性化合物具有发展成为新药的巨大潜力，引起国内外相关领域研究人员的极大关注。同时，也促进了我国海洋放线菌研究工作的全面展开。本文系统综述了海洋放线菌新属种Marinactinospora thermotolerans的分类鉴定、新颖的次级代谢产物的发现及其生物合成机制以及该菌株的全基因组生物信息学分析等方面的最新研究进展，以期能为其他海洋放线菌新属种的分类鉴定、活性次级代谢产物的发现和生物合成机制研究提供借鉴作用。

关键词:海洋放线菌，Marinactinospora thermotolerans，次级代谢产物，生物合成，基因簇

Abstract:

In recent years, great attentions have been paid to marine actinomycetes for their ability to synthesize new metabolites. Some of the synthesized metabolites with new lead structures have demonstrated great potential to be developed as new drugs. This situation has also prompted the development of marine actinomycetes research in China. This review mainly discusses the latest advances regarding Marinactinospora thermotolerans research in terms of the taxonomy, the discovery of novel metabolites, their biosynthesis mechanisms, and the species genome analytical results, etc. M. thermotolerans is considered to be a good model of marine actinobacteria for mining resource research in future.

Key words:Marine actinomycete, Marinactinospora thermotolerans, Metabolites, Biosynthesis, Gene cluster