Influence of native bacterial magnetic particles on mouse immune response

Abstract:

Abstract:[Objective] To study the influence of native bacterial magnetic particles on mouse immune response. [Methods] Ovalbumin was used as an antigen, mixed with complete Freund’s adjuvant, bacterial magnetic particles (BMP) and phosphate buffer solution, to immunize BALB/C mouseAfter 14 days later, we detected the titers of the anti-ovalbumin (IgG) and subtype (IgG1, IgG2a), the proliferation ability of T lymphocyte, and the expression of IL-2, IL-4,IL-10 and IFN-γ. [Results] Compared to the negative control group, the BMP group had the similar level in the titer of specific antibody, the proliferation ability of T lymphocyte and the expression of cytokines (IL-2, IL-4, IL-10 and IFN-γ). [Conclusion] Native BMPs has no significantly influence on mouse immune response.

Key words:Keywords: bacterial magnetic particles; immune response; cytokines; MTT