Lin Wang
Institute of Modern Biopharmaceuticals, School of Life Sciences, Southwest University, Chongqing 400715, ChinaJianping Xie
Institute of Modern Biopharmaceuticals, School of Life Sciences, Southwest University, Chongqing 400715, ChinaSupported by the the National key infectious disease project (2008ZX10003-006，2008ZX10003-001 ), the National Natural Science Foundation (90813019) and the Fundamental Research Funds for the Central Universities（XDJK2009A003）
Abstract：ClpX is a member of Hsp100（heat-shock protein） family which is conserved among organisms. Hsp100/ Clp implicates in stress resistance, intracellular protein turn-over, DNA replication and regulation of gene expression. Tuberculosis remains one of the major threats to human health. In pathogens, ClpX protease plays an important role in the gene expression regulation, pathogenesis, and resistance of immune stress. The structure, substrates and target genes of ClpX are summarized in this study. The biological function of M. tuberculosis ClpX, such as gene expression regulation, pathogenesis, intracellular survival and persistence, evolution and structural feature, substrates is the focus of this summary.
Lin Wang, Jianping Xie. Bacterial ClpX protease structure and function－A review. [J]. Acta Microbiologica Sinica, 2010, 50(10): 1281-1287
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