Metabolic engineering strategies for carboxylic acids production by Saccharomyces cerevisiae—A review

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Metabolic engineering strategies for carboxylic acids production by Saccharomyces cerevisiae—A review
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Fund Project:Supported by the Major state Basic Research Development Program of China (2007CB714306)，by the National Outstanding Doctorate Paper Author Special Fund (200962)，by the Program for New Century Excellent Talents in University (NCET-10-0456) and by the Doctor Candidate Foundation of Jiangnan University

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Abstract:Carboxylatic acids have been widely used in food，pharmaceutical and chemical industries．As a eukaryotic model organism， Saccharomyces cerevisiae is thought as cell factory to produce organic acids through manipulating metabolic pathway．In this review，we addressed the metabolic engineering strategies to construct a high titer route converting pyruvate to target carboxylate，and to explore how to divert the carbon flux to desired product from ethanol．Furthermore，we also discussed the mechanisms for carboxylate transport and energy involved in． Finally，the relevant strategies for development in future are proposed．

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Guoqiang Xu, Liming Liu, Jian Chen. Metabolic engineering strategies for carboxylic acids production by Saccharomyces cerevisiae—A review. [J]. Acta Microbiologica Sinica, 2011, 51(12): 1571-1577

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Received:May 18,2011
Revised:June 20,2011
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