HE Bo
Key Laboratory of Microbial Engineering under the Educational Committee in Chongqing, Department of Microbiology, College of Basic Medical Sciences, Army Medical University, Chongqing, ChinaJIANG Xinyu
Key Laboratory of Microbial Engineering under the Educational Committee in Chongqing, Department of Microbiology, College of Basic Medical Sciences, Army Medical University, Chongqing, ChinaLIAO Jianglin
Key Laboratory of Microbial Engineering under the Educational Committee in Chongqing, Department of Microbiology, College of Basic Medical Sciences, Army Medical University, Chongqing, China;Department of Cardiovascular Medicine, the Southwest Hospital of Army Medical University, Chongqing, ChinaLU Shuguang
Key Laboratory of Microbial Engineering under the Educational Committee in Chongqing, Department of Microbiology, College of Basic Medical Sciences, Army Medical University, Chongqing, ChinaLE Shuai
Key Laboratory of Microbial Engineering under the Educational Committee in Chongqing, Department of Microbiology, College of Basic Medical Sciences, Army Medical University, Chongqing, China1.Key Laboratory of Microbial Engineering under the Educational Committee in Chongqing, Department of Microbiology, College of Basic Medical Sciences, Army Medical University, Chongqing, China;2.Department of Cardiovascular Medicine, the Southwest Hospital of Army Medical University, Chongqing, China
This work was supported by the National Key Research and Development Program of China (2021YFA0911200).
In the post-antibiotic era, phage therapy becomes a candidate for treating drug-resistant bacteria. Phages are diverse, and jumbo phages are a class of phages with genomes longer than 200 kb. Their large genomes carry abundant functional genes with scattered distribution. Jumbo phages have a variety of unique biological characteristics, such as oversized phage particles, unique replication cycles, and unique structures such as the nucleus-like compartment, the “inner body”, and the long-wavy curly tail fiber. This paper reviews the research progress in jumbo phages, focusing on their biological characteristics, genomes, evolution, and special replication mechanisms and structures. Furthermore, this review explores the application potential of jumbo phages in the treatment of drug-resistant bacterial infection, environmental management, aquaculture, and biocontrol, aiming to provide reference and implications for the research and application of jumbo phages.
HE Bo, JIANG Xinyu, LIAO Jianglin, LU Shuguang, LE Shuai. Research progress in jumbo phages. [J]. Acta Microbiologica Sinica, 2025, 65(3): 1017-1032
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