Molecular mechanism of co-culturing Bacillus megaterium and Ketogulonigenium vulgare—A review

Abstract:

Abstract: Co-culturing Bacillus megaterium and Ketogulonigenium vulgare is widely applied to 2-keto-gulonic acid production． For optimizing the process，numerous researchers studied on the symbiotic molecular mechanism of the coculture process． The research was promoted greatly owing to omics technologies，bioinformatics，high throughput technologies and physiology． Recently，the proteomic，metabolomic，comparative genomics and transcriptomics were performed to the research． These omics data provided us the interaction network of the artificial ecosystem in multilevel．Combining with the physiological validation based on the high throughput method，we can elucidate the molecular mechanism in detail，which will facilitate us to develop strategies for metabolic engineering． The paper reviewed the recent developments of symbiotic molecular mechanism research in this co-culture process and its applications． In addition，we propose the future research needs.