Structural classification and functional analysis of aromatic polyketide cyclases－A review

Abstract:

Abstract: Polyketides represent a large group of natural products with diverse structures and biological activities, which could be divided into two structural types: aromatic polyketides and complex polyketides. Cyclases are key enzymes involved in the early tailoring reactions after polyketide chain synthesis; they act in concert with other early tailoring enzymes to control the folding and cyclization pattern of aromatic polyketides. Therefore, they are the key determinants of the final polyketide scaffold. Here, we classified cyclases involved in aromatic polyketide biosynthesis based on their sequences and structures. The reactions catalyzed by these cyclases and the possible catalytic mechanisms were described. We also described the research progress on the characterization of cyclases in jadomycin B biosynthesis.

Key words:Keywords: polyketide post-modification enzymes; cyclase; crystal structure; catalytic mechanism