Research progress in molecular determinants of neuraminidase, polymerase basic protein 2 and nonstructural protein 1, related to virulence of influenza A virus - A review

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Research progress in molecular determinants of neuraminidase, polymerase basic protein 2 and nonstructural protein 1, related to virulence of influenza A virus - A review
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                        Min GuMin Gu
Animal Infectious Disease Laboratory, College of Veterinary Medicine,Yangzhou University, Yangzhou 225009,China
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Daxin PengDaxin Peng
Animal Infectious Disease Laboratory, College of Veterinary Medicine,Yangzhou University, Yangzhou 225009,China
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Xiufan LiuXiufan Liu
Animal Infectious Disease Laboratory, College of Veterinary Medicine,Yangzhou University, Yangzhou 225009,China
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Fund Project:Supported by the Key Project of Chinese National Programs for Fundamental Research and Development (2011CB505001 and 2011CB505003), by the Important National Science & Technology Specific Projects (2008ZX10004-013)

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Abstract:

Abstract: It is gradually recognized that host specificity and pathogenicity of influenza A virus could also be affected by proteins other than hemagglutinin (HA) due to its polygenic nature. In this review, detailed description was focused mainly on neuraminidase (NA), polymerase basic protein 2 (PB2) and nonstructural protein 1 (NS1), especially their molecular determinants associated with virulence and host range restriction of influenza A virus.

Key words:Keywods: influenza A virus; NA; PB2; NS1; virulence; host range; review

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Min Gu, Daxin Peng, Xiufan Liu. Research progress in molecular determinants of neuraminidase, polymerase basic protein 2 and nonstructural protein 1, related to virulence of influenza A virus - A review. [J]. Acta Microbiologica Sinica, 2011, 51(1): 7-13

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Received:June 25,2010
Revised:September 06,2010
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