Microbial NAD synthetase and its inhibitors - A review

Abstract:

Abstract: Nicotinamide - adenine dinucleotide (phosphate) (NAD(P)) metabolism involves many fundamental cellular events, such as energy metabolism, maintenance of redox homeostasis and regulation of cell longevity. Inhibitors of essential enzymes of NAD(P) biosynthetic pathways might be promising leads for novel antibiotics, such as the NAD synthase inhibitors. This review described the crystal structural, functional properties, regulator and structure-based inhibitors design for NAD synthase. This might provide the basis for developing NAD-based therapeutics.

Key words:Keywords: NAD synthetase; crystal structural; structure-based inhibitors design; NrtR family