Biosynthetic pathway and synthetic strategy of spinosad—A review

Home > Archive>Volume 51, Issue 11, 2011 >1431-1439

Biosynthetic pathway and synthetic strategy of spinosad—A review
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                        Yue LiYue Li
School of Life Sciences，Lanzhou University，Lanzhou 730000，China
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Cheng ChangCheng Chang
School of Life Sciences，Lanzhou University，Lanzhou 730000，China
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Keqian YangKeqian Yang
State Key Laboratory of Microbial Resources，Institute of Microbiology，Chinese Academy of Sciences，Beijing 100101， China
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Fund Project:Supported by the Natural Science Foundation of China (NSFC30770240)

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Abstract:

Abstract:Spinosad is a novel macrolide insecticide produced by Saccharopolyspora spinasa，widely used in agriculture．Here its biosynthetic pathway，and key regulatory nodes were reviewed and analyzed．A synthetic strategy to reprogram spinosad biosynthetic pathway was proposed．

Key words:Keywords: spinosad，Saccharopolyspora spinosa，biosynthetic pathway，metabolic regulation analysis，synthetic biology

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Yue Li, Cheng Chang, Keqian Yang. Biosynthetic pathway and synthetic strategy of spinosad—A review. [J]. Acta Microbiologica Sinica, 2011, 51(11): 1431-1439

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Received:April 15,2011
Revised:May 19,2011
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