Detection and description of avian hepatitis E virus isolated in China—A review

Abstract:

Abstract:Avian hepatitis E virus (HEV)，a member of Hepeviridae family，is genetically and antigenically related with human and swine HEV in the family． Since its discovery，avian HEV infection has been investigated in many countries from serology and molecular epidemiology studies． At present，five complete or near complete genomes of avian HEV isolates were reported in GenBank and were divided into three genotypes．The complete genome of avian HEV contains 3 ORFs of which ORF2 gene encodes capsid protein containing the primary epitopes of viral particles and is target gene for serodiagnostic antigen and vaccine candidate． Because avian HEV infection has significant impact on the poultry industry and potential zoonotic transmission，the researches on avian HEV have been given much attention． We here give a broad review of the research update on the aetiology，pathogenesis and the antigenicity of capsid protein of avian HEV based on identification of Chinese avian HEV isolate．