Norovirus epidemic strain GⅡ.4 evolution-A review

Home > Archive>Volume 52, Issue 12, 2012 >1431-1438

Norovirus epidemic strain GⅡ.4 evolution-A review
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                        Qingping WuQingping Wu
Guangdong Institute of Microbiology，State Key Laboratory of Applied Microbiology (Ministry-Guangdong Province Jointly Breeding Base)，South China，Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application，Guangdong Open Laboratory of Applied Microbiology，Guangzhou 510070，China
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Liang XueLiang Xue
Guangdong Institute of Microbiology，State Key Laboratory of Applied Microbiology (Ministry-Guangdong Province Jointly Breeding Base)，South China，Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application，Guangdong Open Laboratory of Applied Microbiology，Guangzhou 510070，China
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Jumei ZhangJumei Zhang
Guangdong Institute of Microbiology，State Key Laboratory of Applied Microbiology (Ministry-Guangdong Province Jointly Breeding Base)，South China，Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application，Guangdong Open Laboratory of Applied Microbiology，Guangzhou 510070，China
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Fund Project:Supported by the Strategic Cooperation Project of Guangdong Province and Chinese Academy of Sciences (2009B091300140) and by the National Key Technology Research and Development Program (2012BAK08B07)

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Abstract:

Abstract:Noroviruses are regarded as the leading cause of epidemic gastroenteritis all over the world，with a wealth of genetic diversity．And GⅡ.4 is regarded as the predominant strain，which has constantly infected humans attributed to a fast rate of evolution in the past two ecades． With the discovery of virus binding-receptor and understanding of immune specificity，the research of evolution mechanism of the virus has been continuously developed recently． It has been hypothesized that the receptor switching and antigenic drift maintains GII． 4 persistence in human populations．Also the RNA viruses，high mutation rate and the limited space of genomic variation have also affected the direction of norovirus evolution.

Key words:Keywords: norovirus，genetic diversity，capsid protein，evolution，receptor binding，immunogenicity

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Qingping Wu, Liang Xue, Jumei Zhang. Norovirus epidemic strain GⅡ.4 evolution-A review. [J]. Acta Microbiologica Sinica, 2012, 52(12): 1431-1438

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Received:August 04,2012
Revised:October 17,2012
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Online: December 04,2012
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