Identification of Th cell epitopes on ClfA adhesin of Staphylococcus aureus and characterization of their role in immunity

Home > Archive>Volume 53, Issue 9, 2013 >966-975

Identification of Th cell epitopes on ClfA adhesin of Staphylococcus aureus and characterization of their role in immunity
DOI:
                        
                    
CSTR:
                        
                    
Author:
                        Yang LiYang Li
Key Laboratory of Zoonosis，Ministry of Education，Institute of Zoonosis，Jilin University，Changchun 130062，China
Find this author on All Journals
Find this author on BaiDu
Search for this author on this site
Zhijie LiZhijie Li
State Key Laboratory of Veterinary Biotechnology，Harbin Veterinary Research Institute，Chinese Academy of Agricultural Sciences，Harbin 150001，China
Find this author on All Journals
Find this author on BaiDu
Search for this author on this site
Yagang LiYagang Li
Fourth Hospital of Jilin University，Changchun 130062，China
Find this author on All Journals
Find this author on BaiDu
Search for this author on this site
Junfeng YeJunfeng Ye
First Hospital of Jilin University，Changchun 130021，China
Find this author on All Journals
Find this author on BaiDu
Search for this author on this site

                    
Affiliation:
Clc Number:
Fund Project:Supported by National Natural Science Foundation of China (81100326)，by the China Postdoctoral Science Foundation (2012M520684)，by the Basic Research Project of Jilin University (450060445322)，by the Jilin University Personnel Development Fund (4305050102Q5)，by the Foundation of Jilin Province Technological Committee (20090737) and by the Jilin Province Postdoctoral Science Foundation (801130020428)

Article

Figures

Metrics

Reference

Cited by

Materials

Comments

Abstract:

Abstract:［Objective］The ClfA adhesin of Staphylococcus aureus is an excellent vaccine candidate antigen． CD4 + T cells play central roles during immune responses，but their functional contributions to Staphylococcus aureus in fection have yet to be evaluated．［Methods］By using the SYFPEITHI prediction algorithm，we identified and characterized four Th epitopes within the ClfA adhesin.［Results］Peptide C335 was I-Ed restricted Th1 type epitopes; peptides C214，C286，and C436 were I-Ad restricted Th2 type epitope.［Conclusion］ The identification of these epitopes is important to evaluate and optimize the vaccine-primed protection against Staphylococcus aureus infection.

Key words:Keywords: Staphylococcus aureus，ClfA，CD4 + T cell，Epitope

Get Citation

Yang Li, Zhijie Li, Yagang Li, Junfeng Ye. Identification of Th cell epitopes on ClfA adhesin of Staphylococcus aureus and characterization of their role in immunity. [J]. Acta Microbiologica Sinica, 2013, 53(9): 966-975

Copy

Article Metrics

Abstract:
PDF:
HTML:
Cited by:

History

Received:March 28,2013
Revised:May 16,2013
Adopted:
Online: August 29,2013
Published:

Get Citation

Related Videos

Share

Article Metrics

History

Article QR Code