Progress in endogenous plasmid curing of bacteria—A review

Home > Archive>Volume 53, Issue 11, 2013 >1142-1148

Progress in endogenous plasmid curing of bacteria—A review
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                        Jun FengJun Feng
Key Laboratory of Molecular Microbiology and Technology for Ministry of Education，College of Life Sciences，Nankai University，Tianjin 300071，China
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Wei ZhangWei Zhang
Key Laboratory of Molecular Microbiology and Technology for Ministry of Education，College of Life Sciences，Nankai University，Tianjin 300071，China
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Cunjiang SongCunjiang Song
Key Laboratory of Molecular Microbiology and Technology for Ministry of Education，College of Life Sciences，Nankai University，Tianjin 300071，China
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Fund Project:Supported by the Key Project of China National Programs for Fundamental Research and Development (2012CB725204)，by the National Programs for High Technology Research and Development of China (2012AA021505) and by the National Natural Science Foundation of China (31070039，170030，51073081)

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Abstract:

Abstract:To investigate the functions of the bacteria endogenous plasmid，which include bacterial drug resistance，symbiosis，capsular formation and heavy metal resistance，the endogenous plasmid needs to be cured first． We reviewed physical，chemical and molecular biological methods of endogenous plasmid curing，clarified the curing principles．The prospective of research on plasmid curing was also discussed，based on our own studies．

Key words:Keywords: plasmid curing，curing methods，curing mechanisms

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Jun Feng, Wei Zhang, Cunjiang Song. Progress in endogenous plasmid curing of bacteria—A review. [J]. Acta Microbiologica Sinica, 2013, 53(11): 1142-1148

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Received:March 23,2013
Revised:June 04,2013
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Online: November 11,2013
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