PTTG1 enhances Hepatitis B Virus replication through P53

doi:10.13343/j.cnki.wsxb.20140426

Home > Archive>Volume 55, Issue 7, 2015 >935-941. DOI:10.13343/j.cnki.wsxb.20140426

PTTG1 enhances Hepatitis B Virus replication through P53
DOI:
                        10.13343/j.cnki.wsxb.20140426
                    
CSTR:
                        32112.14.j.AMS.20140426
                    
Author:
                        Shanxin PengShanxin Peng
Chinese Academy of Sciences Key Laboratory of Pathogenic Microbiology and Immunology，Institute of Microbiology，Chinese Academy of Sciences，Beijing 100101，China
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Changfei LiChangfei Li
Chinese Academy of Sciences Key Laboratory of Pathogenic Microbiology and Immunology，Institute of Microbiology，Chinese Academy of Sciences，Beijing 100101，China
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Lu SunLu Sun
Chinese Academy of Sciences Key Laboratory of Pathogenic Microbiology and Immunology，Institute of Microbiology，Chinese Academy of Sciences，Beijing 100101，China
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Songdong MengSongdong Meng
Chinese Academy of Sciences Key Laboratory of Pathogenic Microbiology and Immunology，Institute of Microbiology，Chinese Academy of Sciences，Beijing 100101，China
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Fund Project:Supported by the National Science and Technology Major Protect (2013ZX10002001-003-003) and by the National Natural Science Foundation of China (31230026，81321063，81471960，81102018)

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Abstract:

Abstract:［Objective］To study the effect of pituitary tumor-transforming gene 1 (PTTG1) on Hepatitis B Virus (HBV) replication.［Methods］ The effect and mechanism of PTTG1 on HBV replication were examined by enzyme-linked immunosorbent assay (ELISA)，immunoblot analysis，real-time PCR，dual-luciferase reporter assays and immunoblot analysis.［Results］PTTG1 impairs the repression of P53 on HBV enhancer I and enhancer II through decreasing the protein level of P53，resulting in promotion of HBV replication.［Conclusion］PTTG1 enhances HBV replication through suppression of P53.

Key words:Keywords: pituitary tumor-transforming gene 1，Hepatitis B Virus，P53，replication

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Shanxin Peng, Changfei Li, Lu Sun, Songdong Meng. PTTG1 enhances Hepatitis B Virus replication through P53. [J]. Acta Microbiologica Sinica, 2015, 55(7): 935-941

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Received:September 02,2014
Revised:December 23,2014
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Online: July 02,2015
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