Heran Zhu
College of Animal Science，Fujian Agriculture and Forestry University，Fuzhou 350002，Fujian Province，ChinaJing Ouyang
CAS Key Laboratory of Pathogenic Microbiology and Immunology，Institute of Microbiology，Chinese Academy of Sciences，Beijing 100101，ChinaJi-Long Chen
College of Animal Science，Fujian Agriculture and Forestry University，Fuzhou 350002，Fujian Province，ChinaSupported by the Key Project of Chinese National Programs for Fundamental Research and Development (2015CB910502) and by the National Natural Science Foundation of China (81171943)
Abstract:Long non-coding RNA(lncRNA) is a class of RNA transcripts with length over 200 nucleotides and absence of the ability to encode a functional protein． Although long non-coding RNAs were previously thought as transcriptional noises，increasing evidences have recently shown that they play important roles in a variety of cellular processes through regulating epigenetic modifications and thereby affecting gene transcription，post-transcriptional processing，and protein translation．Importantly，it has been found that abnormal expression or dysregulation of lncRNAs are closely associated with tumorigenesis and host innate immune response to various infections with pathogens． In this review，we will discuss the progresses in understanding the function of lncＲNAs in these processes.
Heran Zhu, Jing Ouyang, Ji-Long Chen. Function and regulation of long non-coding RNAs in tumorigenesis and host innate immunity-A review. [J]. Acta Microbiologica Sinica, 2015, 55(7): 801-812
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