Ruihong Qiao
College of Life Science，Liaoning Normal University，Key Laboratory of Biotechnology and Drug of Liaoning Province，Dalian 116081，Liaoning Province，ChinaKunpeng Xie
College of Life Science，Liaoning Normal University，Key Laboratory of Biotechnology and Drug of Liaoning Province，Dalian 116081，Liaoning Province，ChinaMingjie Xie
College of Life Science，Liaoning Normal University，Key Laboratory of Biotechnology and Drug of Liaoning Province，Dalian 116081，Liaoning Province，ChinaSupported by the Liaoning Provincial Department of Education science general project (L2013412) and by the Dalian Science and Technology Project (2013E13SF108)
Abstract:Bacterial resistance is a threat to public health． Bacterial biofilm formation is one of the main reasons for persistent infection caused by bacteria． Biofilm development is a complex process that involves many factors and genes which play various roles in all stages of the biofilm formation． This review focuses on the gene regulatory mechanisms relate to the biofilm formation of Staphylococcus，the most common pathogen that causes nosocomial infection，as well as the latest developments of pharmacological anti-biofilm therapies． We also address new strategy to treat bacterial infection and the development of drugs and vaccines against biofilm resistance.
Ruihong Qiao, Kunpeng Xie, Mingjie Xie. Progress in gene regulation mechanisms of Staphylococcus biofilm development-A review. [J]. Acta Microbiologica Sinica, 2015, 55(10): 1238-1244
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