Home > Archive>Volume 56, Issue 12, 2016 >1831-1839. DOI:10.13343/j.cnki.wsxb.20160131
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Research progress and prospects of phosphorothioate modification-A review
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    Abstract:

    DNA phosphorothioate modification was the first reported physiological modification in the DNA backbone. Five putative proteins encoded by the five-member dndABCDE gene cluster replaced the non-bridging oxygen in the sugar-phosphate backbone with a sulfur. Phosphorothioate modification occurrs in sequence-selective and Rp stereo-specific manner in diverse bacterial stains. In recent years, researchers have made systemic achievements in this area. To have a comprehensive understanding of this unusual modification, we reviewed the discovery and research progress in DNA phosphorothioate modification and also discussed opportunities and challenges in the future.

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Yali Gao, Zixin Deng, Shi Chen. Research progress and prospects of phosphorothioate modification-A review. [J]. Acta Microbiologica Sinica, 2016, 56(12): 1831-1839

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  • Received:April 02,2016
  • Revised:May 17,2016
  • Online: November 29,2016
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