Streptomyces nucleoid-associated proteins: role in morphological differentiation and secondary metabolism

Abstract:

Streptomyces have a unique and complex morphological differentiation process. The process of aerial hyphae differentiating into spore filaments is accompanied by the biosynthesis of secondary metabolites. The morphological differentiation of Streptomyces involves many steps, such as chromosome replication, condensation and separation. As important components of chromosome structure and the global regulatory factors of bacteria, the nucleoid-associated proteins play an important role in the regulation of morphological differentiation and secondary metabolism of Streptomyces. In this paper, we summarize the structures, functions, regulation of nucleoid-associated proteins and especially their role in morphological differentiation and secondary metabolism of Streptomyces.

Key words:nucleoid-associated proteins;morphological differentiation;secondary metabolism;transcriptional regulation