Role of mitogen-activated protein kinase phosphatase-1 in Mycobacterium tuberculosis infection

doi:10.13343/j.cnki.wsxb.20170014

Home > Archive>Volume 57, Issue 7, 2017 >978-984. DOI:10.13343/j.cnki.wsxb.20170014

Role of mitogen-activated protein kinase phosphatase-1 in Mycobacterium tuberculosis infection
DOI:
                        10.13343/j.cnki.wsxb.20170014
                    
CSTR:
                        32112.14.j.AMS.20170014
                    
Author:
                        Lijun HuangLijun Huang
Institute of Aging Research, Guangdong Medical University, Dongguan 523808, Guangdong Province, China;Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Guangdong Medical University, Dongguan 523808, Guangdong Province, China;The Affiliated Shenzhen Third Hospital, Guangdong Medical University, Shenzhen 518020, Guangdong Province, China
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Gonghua HuangGonghua Huang
Shanghai Institute of Immunology, School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China
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Xinguang LiuXinguang Liu
Institute of Aging Research, Guangdong Medical University, Dongguan 523808, Guangdong Province, China;Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Guangdong Medical University, Dongguan 523808, Guangdong Province, China
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Abstract:

Mitogen-activated protein kinase (MAPK) signaling pathway is one of the most important intracellular signaling pathways in which cells perceive exogenous stimuli and make an effective immune response. Recent studies have shown that the dysregulation of MAPK is highly associated with tuberculosis pathogenesis. The MAPK phosphatases (MKPs) are the prototypic phosphatase that could dephosphorylate the MAPKs, thus play an essential role in the regulation of cell stress, differentiation, proliferation and apoptosis by negatively regulating the activity of MAPKs. Among all the MKPs, MKP-1 has the strongest ability to dephosphorylate MAPKs. In this review, we summarize the role of MKP-1 in Mycobacterium tuberculosis infection and relevant research progress.

Key words:mitogen-activated protein kinases (MAPKs);MAPK phosphatase-1(MKP-1);tuberculosis

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Lijun Huang, Gonghua Huang, Xinguang Liu. Role of mitogen-activated protein kinase phosphatase-1 in Mycobacterium tuberculosis infection. [J]. Acta Microbiologica Sinica, 2017, 57(7): 978-984

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Received:January 06,2017
Revised:February 19,2017
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Online: July 07,2017
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