Correlation of gut microbiota with Parkinson's disease

Abstract:

The large number of gut microbiota (GM) in human body, participating in the material metabolize and energy cycles, regulates the physiological activities of the body. In recent years, many studies demonstrate that the stable state of GM plays an essential role in maintaining the normal function of the brain and nervous system. GM disorder is closely related to some neurological diseases like Parkinson's disease (PD). At present, there are abundant research results on relationship between the pathogenesis of PD and the dysregulation of GM, indicating that GM brings a vital induction effect to the pathogenesis of PD. After reviewing the literature on the correlation of GM with PD and analyzing the change of GM in PD patients, we discuss the relationship between the occurrence of PD and the change of GM. Moreover, we also address the application of faecal transplants treatment in PD treatment in order to provide a reliable theoretical basis for the potential prevention and treatment of PD by regulating GM.

Key words:gut microbiota;Parkinson's disease;lewy body;enteroendocrine cell;faecal transplant