Home > Archive>Volume 58, Issue 11, 2018 >1979-1988. DOI:10.13343/j.cnki.wsxb.20180155
PDF HTML XML Export Cite reminder
Regulatory mechanism and research progress of several common sweeteners on intestinal microbes
Author:
  • Article
    • | |
  • Metrics
    • |
  • Reference [40]
    • |
  • Related [20]
    • | | |
  • Comments
    Abstract:

    Sweeteners are food additives that impart the sweetness to soft drink foods, which can be divided into high-intensity sweeteners and low-calorie sweeteners. At present, the regulatory mechanism of sweeteners on intestinal flora has become one of the hot spots. Sweeteners can affect the ecological balance of the gut microbiota, and then affects the health of the host. More and more data indicates that excessive consumption of sweeteners can cause metabolic dysfunction, and affecting host weight and glucose tolerance. This article reviews the recent research progress of several commonly used sweeteners on intestinal microbial regulation, in order to provide reference for the researchers.

    Reference
    [1] Gardner C, Wylie-Rosett J, Gidding SS, Steffen LM, Johnson RK, Reader D, Lichtenstein AH. Nonnutritive sweeteners:current use and health perspectives:a scientific statement from the American heart association and the American diabetes association. Diabetes Care, 2012, 35(8):1798-1808, doi:10.2337/dc12-9002.
    [2] Carocho M, Morales P, Ferreira ICFR. Sweeteners as food additives in the XXI century:a review of what is known, and what is to come. Food and Chemical Toxicology:An International Journal Published for the British Industrial Biological Research Association, 2017, 107:302-317, doi:10.1016/j.fct.2017.06.046.
    [3] Koyama E, Kitazawa K, Ohori Y, Izawa O, Kakegawa K, Fujino A, Ui M. In vitro metabolism of the glycosidic sweeteners, stevia mixture and enzymatically modified stevia in human intestinal microflora. Food and Chemical Toxicology:An International Journal Published for the British Industrial Biological Research Association, 2003, 41(3):359-374, doi:10.1016/s0278-6915(02)00235-1.
    [4] Nettleton JE, Reimer RA, Shearer J. Reshaping the gut microbiota:impact of low calorie sweeteners and the link to insulin resistance? Physiology & Behavior, 2016, 164:488-493, doi:10.1016/j.physbeh.2016.04.029.
    [5] Uebanso T, Kano S, Yoshimoto A, Naito C, Shimohata T, Mawatari K, Takahashi A. Effects of consuming xylitol on gut microbiota and lipid metabolism in mice. Nutrients, 2017, 9(7):756, doi:10.3390/nu9070756.
    [6] Lee PY, Chin SF, Neoh HM, Jamal R. Metaproteomic analysis of human gut microbiota:where are we heading? Journal of Biomedical Science, 2017, 24(1):36, doi:10.1186/s12929-017-0342-z.
    [7] Bengmark S. Ecological control of the gastrointestinal tract. The role of probiotic flora. Gut, 1998, 42(1):2-7, doi:10.1136/gut.42.1.2.
    [8] Bäckhed F, Ley RE, Sonnenburg JL, Peterson DA, Gordon JI. Host-bacterial mutualism in the human intestine. Science, 2005, 307(5717):1915-1920, doi:10.1126/science.1104816.
    [9] Gill SR, Pop M, DeBoy RT, Eckburg PB, Turnbaugh PJ, Samuel BS, Gordon JI, Relman DA, Fraser-Liggett CM, Nelson KE. Metagenomic analysis of the human distal gut microbiome. Science, 2006, 312(5778):1355-1359, doi:10.1126/science.1124234.
    [10] Hugon P, Dufour JC, Colson P, Fournier PE, Sallah K, Raoult D. A comprehensive repertoire of prokaryotic species identified in human beings. The Lancet Infectious Diseases, 2015, 15(10):1211-1219, doi:10.1016/s1473-3099(15)00293-5.
    [11] Wang BH, Yao MF, Lv LX, Ling ZX, Li LJ. The human microbiota in health and disease. Engineering, 2017, 3(1):71-82, doi:10.1016/J.ENG.2017.01.008.
    [12] Natividad JMM, Verdu EF. Modulation of intestinal barrier by intestinal microbiota:pathological and therapeutic implications. Pharmacological Research, 2013, 69(1):42-51, doi:10.1016/j.phrs.2012.10.007.
    [13] den Besten G, Van Eunen K, Groen AK, Venema K, Reijngoud DJ, Bakker BM. The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism. Journal of Lipid Research, 2013, 54(9):2325-2340, doi:10.1194/jlr.r036012.
    [14] Bäumler AJ, Sperandio V. Interactions between the microbiota and pathogenic bacteria in the gut. Nature, 2016, 535(7610):85-93, doi:10.1038/nature18849.
    [15] Gensollen T, Iyer SS, Kasper DL, Blumberg RS. How colonization by microbiota in early life shapes the immune system. Science, 2016, 352(6285):539-544, doi:10.1126/science.aad9378.
    [16] Thursby E, Juge N. Introduction to the human gut microbiota. Biochemical Journal, 2017, 474(11):1823-1836, doi:10.1042/BCJ20160510.
    [17] Palmnäs MSA, Cowan TE, Bomhof MR, Su J, Reimer RA, Vogel HJ, Hittel DS, Shearer J. Low-dose aspartame consumption differentially affects gut microbiota-host metabolic interactions in the diet-induced obese rat. PLoS One, 2014, 9(10):e109841, doi:10.1371/journal.pone.0109841.
    [18] Bian XM, Chi L, Gao B, Bei G, Tu PC, Ru HY, Lu K. The artificial sweetener acesulfame potassium affects the gut microbiome and body weight gain in CD-1 mice. PLoS One, 2017, 12(6):e0178426, doi:10.1371/journal.pone.0178426.
    [19] Pfeffer M, Ziesenitz SC, Siebert G. Acesulfame K, cyclamate and saccharin inhibit the anaerobic fermentation of glucose by intestinal bacteria. Zeitschrift Für Ernährungswissenschaft, 1985, 24(4):231-235, doi:10.1007/bf02023668.
    [20] Bian XM, Chi L, Gao B, Tu PC, Ru HY, Lu K. Gut microbiome response to sucralose and its potential role in inducing liver inflammation in mice. Frontiers in Physiology, 2017, 8:487, doi:10.3389/fphys.2017.00487.
    [21] Abou-Donia MB, El-Masry EM, Abdel-Rahman AA, Mclendon RE, Schiffman SS. Splenda alters gut microflora and increases intestinal p-glycoprotein and cytochrome p-450 in male rats. Journal of Toxicology & Environmental Health, 2007, 71(21):1415-1429. doi.org/10.1080/15287390802328630.
    [22] Suez J, Korem T, Zeevi D, Zilberman-Schapira G, Thaiss CA, Maza O. Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 2014, 514(7521):181-186, doi:10.1038/nature13793.
    [23] Abou-Donia MB, El-Masry EM, Abdel-Rahman AA, McLendon RE, Schiffman SS. Splenda alters gut microflora and increases intestinal p-glycoprotein and cytochrome p-450 in male rats. Journal of Toxicology and Environmental Health, Part A, 2008, 71(21):1415-1429, doi:10.1080/15287390802328630.
    [24] Rodriguez-Palacios A, Harding A, Menghini P, Himmelman C, Retuerto M, Nickerson KP, Lam M, Croniger CM, McLean MH, Durum SK, Pizarro TT, Ghannoum MA, Ilic S, McDonald C, Cominelli F. The artificial sweetener Splenda promotes gut Proteobacteria, dysbiosis, and myeloperoxidase reactivity in Crohn's disease-like ileitis. Inflammatory Bowel Diseases, 2018, 24(5):1005-1020, doi:10.1093/ibd/izy060.
    [25] Salminen S, Salminen E, Bridges J, Marks V. The effects of sorbitol on the gastrointestinal microflora in rats. Zeitschrift Für Ernährungswissenschaft, 1986, 25(2):91-95, doi:10.1007/bf02020738.
    [26] Lin SH, Chou LM, Chien YW, Chang JS, Lin CI. Prebiotic effects of xylooligosaccharides on the improvement of microbiota balance in human subjects. Gastroenterology Research and Practice, 2016, 2016(6):5789232, doi:10.1155/2016/5789232.
    [27] Watanabe M, Ozaki T, Hirata Y, Yoshikuni Y, Kimura K, Ishiko H, Yokota E, Uchino U, Mitsuoka T. Effect of lactitol on intestinal bacteria. BIFIDUS——Flores, Fructus et Semina, 1995, 9(1):19-26, doi:10.11209/jim1987.9.19.
    [28] Piva A, Casadei G, Gatta PP, Luchansky JB, Biagi G. Effect of lactitol, lactic acid bacteria, or their combinations (synbiotic) on intestinal proteolysis in vitro, and on feed efficiency in weaned pigs. Canadian Journal of Animal Science, 2005, 85(3):345-353, doi:10.4141/a04-087.
    [29] White WL, Coveny AH, Robertson J, Clements KD. Utilisation of mannitol by temperate marine herbivorous fishes. Journal of Experimental Marine Biology and Ecology, 2010, 391(1/2):50-56, doi:10.1016/j.jembe.2010.06.007.
    [30] Gao S, Qi XH, Hart DJ, Gao HR, An YF. Expression and characterization of levansucrase from Clostridium acetobutylicum. Journal of Agricultural and Food Chemistry, 2017, 65(4):867-871, doi:10.1021/acs.jafc.6b05165.
    [31] Suzuki K, Endo Y, Uehara M, Yamada H, Goto S, Imamura M, Shiozu S. Effect of lactose, lactulose and sorbitol on mineral utilization and intestinal flora. Nipponyo Eiyo Shokuryo Gakkaishi, 1985, 38(1):39-42, doi:10.4327/jsnfs.38.39.
    [32] Söderling EM, Ekman TC, Taipale TJ. Growth inhibition of Streptococcus mutans with low xylitol concentrations. Current Microbiology, 2008, 56(4):382-385, doi:10.1007/s00284-007-9076-6.
    [33] Campus G, Cagetti MG, Sale S, Petruzzi M, Solinas G, Strohmenger L, Lingström P. Six months of high-dose xylitol in high-risk caries subjects-a 2-year randomised, clinical trial. Clinical Oral Investigations, 2013, 17(3):785-791, doi:10.1007/s00784-012-0774-5.
    [34] Salminen S, Salminen E, Koivistoinen P, Bridges J, Marks V. Gut microflora interactions with xylitol in the mouse, rat and man. Food & Chemical Toxicology:An International Journal Published for the British Industrial Biological Research Association, 1985, 23(11):985-990, doi:10.1016/0278-6915(85)90248-0.
    [35] Ridlon JM, Kang DJ, Hylemon PB. Bile salt biotransformations by human intestinal bacteria. Journal of Lipid Research, 2006, 47(2):241-259, doi:10.1194/jlr.r500013-jlr200.
    [36] Söderling E, Elsalhy M, Honkala E, Fontana M, Flannagan S, Eckert G, Kokaras A, Paster B, Tolvanen M, Honkala S. Effects of short-term xylitol gum chewing on the oral microbiome. Clinical Oral Investigations, 2015, 19(2):237-244, doi:10.1007/s00784-014-1229-y.
    [37] Yatsunenko T, Rey FE, Manary MJ, Trehan I, Dominguez-Bello MG, Contreras M, Magris M, Hidalgo G, Baldassano RN, Anokhin AP, Heath AC, Warner B, Reeder J, Kuczynski J, Caporaso JG, Lozupone CA, Lauber C, Clemente JC, Knights D, Knight R, Gordon JI. Human gut microbiome viewed across age and geography. Nature, 2012, 486(7402):222-227, doi:10.1038/nature11053.
    [38] Ballongue J, Schumann C, Quignon P. Effects of lactulose and lactitol on colonic microflora and enzymatic activity. Scandinavian Journal of Gastroenterology, 1997, 32(S222):41-44, doi:10.1080/00365521.1997.11720716.
    [39] Piva A, Prandini A, Fiorentini L, Morlacchini M, Galvano F, Luchansky JB. Tributyrin and lactitol synergistically enhanced the trophic status of the intestinal mucosa and reduced histamine levels in the gut of nursery pigs. Journal of Animal Science, 2002, 80(3):670-680, doi:10.2527/2002.803670x.
    [40] Thabuis C, Herbomez AC, Desailly F, Ringard F, Wils D, Guérin-Deremaux L. Prebiotic-like effects of sweetPearl® maltitol through changes in caecal and fecal parameters. Food and Nutrition Sciences, 2012, 3(10):1375-1381, doi:10.4236/fns.2012.310180.
    Cited by
    Comments
    Comments
    分享到微博
    Submit
Get Citation

Chengxu Cao, Junrui Wu, Rina Wu. Regulatory mechanism and research progress of several common sweeteners on intestinal microbes. [J]. Acta Microbiologica Sinica, 2018, 58(11): 1979-1988

Copy
Share
Article Metrics
  • Abstract:1098
  • PDF: 3468
  • HTML: 5967
  • Cited by: 0
History
  • Received:April 10,2018
  • Revised:August 07,2018
  • Online: November 06,2018
Article QR Code
  • WeChat ID
  • Mobile Terminal

Acta Microbiologica Sinica ® 2025 All Rights Reserved