Research progress in microbial production and application of ectoines
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    Abstract:

    Extremophiles thrive in environments considered extreme for human life. To adapt to the extreme environments, a distinct abundant group of microbial bioactive molecules was produced in the extremophiles. Ectoine, as a compatible solute, was discovered originally in the halophilic bacterium and enable the bacteria to survive in salty environments. In addition to be functional as an osmotic counterweight, ectoine was able to protect proteins, nucleic acids, cell membranes and even the whole cells against various stressors such as heating, drying, freezing and radiation. Therefore, ectoines exhibit great potential for the application in the fields of biomolecule protection, biomedicine and biotechnology. With the development of synthetic biology and metabolic engineering, the traditional approach for ectoine production in halophilic bacteria was replaced by heterologous production of ectoines in the non-halophilic bacteria. In this paper, we overviewed the research progress on the microbial production and application of ectoines, which provides an important reference for the future development and commercial application of ectoines.

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Shan Zhang, Meng Hu, Yongzhi He, Zhiyang Dong. Research progress in microbial production and application of ectoines. [J]. Acta Microbiologica Sinica, 2021, 61(8): 2250-2263

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History
  • Received:September 10,2020
  • Revised:December 25,2020
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  • Online: August 04,2021
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